Cyclophosphamide Promotes Arrested Development of the Dental Root in Mice

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Cyclophosphamide Promotes Arrested Development of the Dental Root in Mice

Persistent ID (NDL): info:ndljp/pid/11512205

Material type: 博士論文

Author: Matsuo, Satoruほか

Publisher: 硬組織再生生物学会

Publication date: 2020-03-14

Material Format: Digital

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Name of awarding university/degree: 福岡歯科大学,博士（歯学）

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Note (General)：: <p>Cyclophosphamide (CPA) is a commonly used chemotherapeutic agent to treat cancer. Among its many side effects is the well-known consequence on toot...

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Material Type: 博士論文
Title: Cyclophosphamide Promotes Arrested Development of the Dental Root in Mice
Author/Editor: Matsuo, Satoru
Toda-Nakamura, Masako
Oka, Kyoko
Kajiya, Hiroshi
Ogata, Kayoko
Ishii, Hanako
Ozaki, Masao
Ohno, Jun
Publication, Distribution, etc.: 硬組織再生生物学会
Publication Date: 2020-03-14
Publication Date (W3CDTF): 2020-03-14
Alternative Title: Cyclophosphamide Promotes Arrested Development of the Dental Root in Mice
Degree grantor/type: 福岡歯科大学
Date Granted: 2020-03-14
Date Granted (W3CDTF): 2020-03-14
Dissertation Number: 甲第314号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第314号
Text Language Code: eng
Subject Heading: Tooth root
Cyclophosphamide
Hertwig’s epithelial root sheath
Epithelial-to-mesenchymal transition
Note (General): <p>Cyclophosphamide (CPA) is a commonly used chemotherapeutic agent to treat cancer. Among its many side effects is the well-known consequence on tooth development when administered at early ages. This study elucidated the effects of CPA on development of the mandibular molar in mice. Mice received a single intraperitoneal injection of CPA at different doses and development times. CPA treatment led to weight loss and alopecia but had no effect on disturbances in tooth eruption or crown shape. However, at higher doses, there was arrested root development and early apical foramen closure histologically related to the formation of the cervical loop structure in the apical portion of the root. In cell culture experiments, the Hertwig's epithelial root sheath cell line (HERS01a) was cultured with or without CPA. At high doses of CPA, HERS01a cells showed decreases in E-cadherin expression, while N-cadherin expression was upregulated, indicating that this cadherin switch may promote an epithelial-to-mesenchymal transition (EMT)-like phenomenon. These findings suggest that administration of high doses of CPA can lead to arrested root development of the molars and an EMT-like phenomenon.</p>
2019年度
Persistent ID (NDL): info:ndljp/pid/11512205
https://dl.ndl.go.jp/pid/11512205
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2020-07-06T20:31:19+09:00
Date Created (W3CDTF): 2020-06-17
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://id.nii.ac.jp/1167/00000099/
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp