Accumulation of microdamage in subchondral bone at the femoral head in patients with end-stage osteoarthritis of the hip

• Material Type: 博士論文
• Title: Accumulation of microdamage in subchondral bone at the femoral head in patients with end-stage osteoarthritis of the hip
• Author/Editor: 嶌村, 将志
• Author Heading: 嶌村, 将志
• Publication Date: 2019-06-25
• Publication Date (W3CDTF): 2019-06-25
• Degree grantor/type: 香川大学
• Date Granted: 2019-06-25
• Date Granted (W3CDTF): 2019-06-25
• Dissertation Number: 甲第723号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第723号
• Text Language Code: eng
• Alias of Author: Shimamura, Masashi
• Subject Heading: Bone microdamage; Femoral head; Histomorphometry; Osteoarthritis; Bone modeling
• Target Audience: 一般
• Note (General): AbstractIn end-stage osteoarthritis (OA) of the hip, the effect of bone metabolism with and without cartilage is unclear. In this study, we aimed to investigate histomorphology and microdamage in the subchondral bone of the femoral head in areas with and without articular cartilage in patients with end-stage OA. Nineteen femoral heads were evaluated in 10 women who underwent total hip arthroplasty for OA and in nine cadaveric controls (CNT). Chondral thickness and subchondral bone plate thickness (SBP.Th) were measured in 5-mm-wide areas where cartilage was lost (area A) or preserved (area B) in OA and in corresponding areas in the load-bearing portion of the femoral head in the CNT. Histomorphometry and microdamage in 5 × 5-mm areas of cancellous bone were assessed. SBP.Th and bone volume were significantly greater in area A than in area B or in the CNT. Osteoid volume was significantly greater in area A than in area B or in the CNT. There was no significant difference in eroded surface between area A and CNT. Microcrack density was significantly greater in area A than in area B or in the CNT. Although accumulation of microdamage was caused by concentration of stress on the subchondral bone in the cartilage loss area in end-stage OA, remodeling for microdamage repairing mechanism was not enhanced. It was considered that the subchondral cancellous bone volume was increased because of modeling, not remodeling, by stress concentration due to articular cartilage loss.
• DOI: info:doi/10.1007/s00774-019-00988-z; https://doi.org/info:doi/10.1007/s00774-019-00988-z
• Persistent ID (NDL): info:ndljp/pid/11512857; https://dl.ndl.go.jp/pid/11512857
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-07-07T14:12:56+09:00
• Date Created (W3CDTF): 2020-10-27
• Format (IMT): PDF
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): https://kagawa-u.repo.nii.ac.jp/records/399
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp