High-pressure carbon monoxide and oxygen mixture is effective for lung preservation

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High-pressure carbon monoxide and oxygen mixture is effective for lung preservation

Persistent ID (NDL): info:ndljp/pid/11512860

Material type: 博士論文

Author: 藤原, 敦史

Publisher: -

Publication date: 2019-12-25

Material Format: Digital

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Name of awarding university/degree: 香川大学,博士（医学）

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Note (General)：: (1) Background: Heme oxygenase-1 (HO-1) degrades heme and generates carbon monoxide (CO), producing various anti-inflammatory, anti-oxidative, and ant...

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Material Type: 博士論文
Title: High-pressure carbon monoxide and oxygen mixture is effective for lung preservation
Author/Editor: 藤原, 敦史
Author Heading: 藤原, 敦史
Publication Date: 2019-12-25
Publication Date (W3CDTF): 2019-12-25
Degree grantor/type: 香川大学
Date Granted: 2019-12-25
Date Granted (W3CDTF): 2019-12-25
Dissertation Number: 甲第728号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第728号
Text Language Code: eng
Alias of Author: Fujiwara, Atsushi
Subject Heading: carbon monoxide
high-pressure gas
ischemia-reperfusion injury
lung preservation
Target Audience: 一般
Note (General): (1) Background: Heme oxygenase-1 (HO-1) degrades heme and generates carbon monoxide (CO), producing various anti-inflammatory, anti-oxidative, and anti-apoptotic effects. This study aimed to confirm the effects of CO on the ischemia–reperfusion injury (IRI) of donor lungs using a high-pressure gas (HPG) preservation method.
(2) Methods: Donor rat and canine lungs were preserved in a chamber filled with CO (1.5 atm) and oxygen (O2; 2 atm) and were ventilated with either CO and O2 mixture (CO/O2 group) or air (air group) immediately before storage. Rat lungs were subjected to heterotopic cervical transplantation and evaluated after reperfusion, whereas canine lungs were subjected to allogeneic transplantation and evaluated.
(3) Results: Alveolar hemorrhage in the CO/O2 group was significantly milder than that in the air group. mRNA expression levels of HO-1 remained unchanged in both the groups; however, inflammatory mediator levels were significantly lower in the CO/O2 group than in the air group. The oxygenation of graft lungs was comparable between the two groups, but lactic acid level tended to be higher in the air group.
(4) Conclusions: The HO-1/CO system in the HPG preservation method is effective in suppressing IRI and preserving donor lungs.
DOI: info:doi/10.3390/ijms20112719
https://doi.org/info:doi/10.3390/ijms20112719
Persistent ID (NDL): info:ndljp/pid/11512860
https://dl.ndl.go.jp/pid/11512860
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2020-07-07T14:12:56+09:00
Date Created (W3CDTF): 2020-10-27
Format (IMT): PDF
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): https://kagawa-u.repo.nii.ac.jp/records/413
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp