Failure to confirm a sodium-glucose cotransporter 2 inhibitor-induced hematopoietic effect in non-diabetic rats with renal anemia

• Material Type: 博士論文
• Title: Failure to confirm a sodium-glucose cotransporter 2 inhibitor-induced hematopoietic effect in non-diabetic rats with renal anemia
• Author/Editor: 山﨑, 大輔
• Author Heading: 山﨑, 大輔
• Publication Date: 2020-06-25
• Publication Date (W3CDTF): 2020-06-25
• Alternative Title: 非糖尿病性腎性貧血ラットにおいてSGLT2阻害薬は造血効果を示さない
• Degree grantor/type: 香川大学
• Date Granted: 2020-06-25
• Date Granted (W3CDTF): 2020-06-25
• Dissertation Number: 甲第751号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第751号
• Text Language Code: eng
• Alias of Author: Yamazaki, Daisuke
• Subject Heading: Erythropoietin; Renal anemia; Sodium-glucose cotransporter 2 inhibitor
• Target Audience: 一般
• Note (General): Aims/introduction: Clinical studies have shown that treatment with inhibitors of sodium-glucose cotransporter 2 (SGLT2) significantly increases the hematocrit in patients with type 2 diabetes. To investigate whether SGLT2 inhibitors directly promote erythropoietin production independently on blood glucose reduction, the hematopoietic effect of the specific SGLT2 inhibitor, luseogliflozin, was examined in non-diabetic rats with renal anemia.Materials and methods: Renal anemia was induced by treatment with adenine (200 or 600 mg/kg/day, orally for 10 days) in non-diabetic Wistar-Kyoto or Wistar rats, respectively. Luseogliflozin (10 mg/kg bodyweight) or vehicle (0.5% carboxymethyl cellulose) was then administered for 6 weeks. The hematocrit and the hemoglobin (Hb), blood urea nitrogen, plasma creatinine, and plasma erythropoietin levels were monitored.; This is the Publisher's Version of the following article: Failure to confirm a sodium-glucose cotransporter 2 inhibitor-induced hematopoietic effect in non-diabetic rats with renal anemia; Journal of diabetes investigation; (2019) doi: 10.1111/jdi.13205, which has been published in final form at https://doi.org/10.1111/jdi.13205.
• DOI: info:doi/10.1111/jdi.13205; https://doi.org/info:doi/10.1111/jdi.13205
• Persistent ID (NDL): info:ndljp/pid/11526075; https://dl.ndl.go.jp/pid/11526075
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-08-11T22:41:34+09:00
• Date Created (W3CDTF): 2020-10-12
• Format (IMT): PDF
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Related Material: This is the Publisher's Version of the following article: Failure to confirm a sodium-glucose cotransporter 2 inhibitor-induced hematopoietic effect in non-diabetic rats with renal anemia; Journal of diabetes investigation; (2019) doi: 10.1111/jdi.13205, which has been published in final form at https://doi.org/10.1111/jdi.13205.
• Periodical Title (URI): https://kagawa-u.repo.nii.ac.jp/records/148
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp