Prevalence of and factors associated with dysfunctional low back pain in patients with rheumatoid arthritis

• Material Type: 博士論文
• Title: Prevalence of and factors associated with dysfunctional low back pain in patients with rheumatoid arthritis
• Author/Editor: Miura, Kazuto
• Publication Date: 2019-09-20
• Publication Date (W3CDTF): 2019-09-20
• Alternative Title: 関節リウマチ症例における機能障害性腰痛の頻度と関連する因子
• Degree grantor/type: 新潟大学
• Date Granted: 2019-09-20
• Date Granted (W3CDTF): 2019-09-20
• Dissertation Number: 甲第4636号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲第4636号
• Text Language Code: eng
• Subject Heading: Rheumatoid arthritis; Low back pain; Body mass index; Spinopelvic malalignment; Vertebral fractures; Methotrexate
• Note (General): Purpose: To investigate the prevalence of and factors associated with dysfunctional low back pain (LBP) in patients with rheumatoid arthritis (RA). Methods: This cross-sectional study included 1276 RA outpatients from two hospitals. The Roland–Morris Disability Questionnaire was used to address the functional–dysfunctional state criterion. Clinical variables, such as medical status, disease activity, bone mineral density, and spinopelvic alignment parameters, were compared between patients with and without dysfunctional LBP. Results: Mean age and disease duration were 64.6 and 13.4 years, respectively; the prevalence of dysfunctional LBP was 32.8%. On univariate analysis, significant differences existed in many variables, except sex, body weight, C-reactive protein (CRP) level, and prevalence of biological agent users, between patients with and without dysfunctional LBP. Multivariate logistic regression analysis revealed body mass index (BMI; odds ratio [OR], 1.116; P<0.001), onset age of RA (OR, 1.020; P=0.020), disease duration of RA (OR, 1.043; P<0.001), methotrexate (MTX) use (OR, 0.609; P=0.007), vertebral fractures (OR, 2.189; P=0.001), vertebral endplate and/or facet erosion (OR, 1.411; P=0.043), disease activity score (DAS) in 28 joints-CRP (DAS-28CRP) (OR, 1.587; P=0.001), pelvic tilt (PT; OR, 1.023; P=0.019), and sagittal vertical axis (SVA; OR, 1.007; P=0.043) as associated factors. Conclusion: The factors associated with dysfunctional LBP in patients with RA were more vertebral fractures, higher DAS28CRP, vertebral endplate and/or facet erosion, higher BMI, longer disease duration, greater PT, older onset age, greater SVA, and less MTX use. Strictly controlling patients’ body weight and disease activity with MTX and avoiding spinopelvic malalignment through vertebral fracture prevention are important.; European Spine Journal. 2019, 28(5), 976-982.; 新大院博(医)甲第896号; 元資料の権利情報 : 【○!C】 The Author(s) 2019
• DOI: info:doi/10.1007/s00586-019-05938-x; https://doi.org/info:doi/10.1007/s00586-019-05938-x
• Persistent ID (NDL): info:ndljp/pid/11526129; https://dl.ndl.go.jp/pid/11526129
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-08-11T22:41:34+09:00
• Date Created (W3CDTF): 2020-07-08
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10191/00051717
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp