Effect of All-Trans-Retinoic Acid on the Development of Chronic Hypoxia-Induced Pulmonary Hypertension

• Material Type: 博士論文
• Title: Effect of All-Trans-Retinoic Acid on the Development of Chronic Hypoxia-Induced Pulmonary Hypertension
• Author/Editor: Zhang, Erquan
• Author Heading: Zhang, Erquan
• Publication, Distribution, etc.: 三重大学
• Publication Date: 2015-07-15
• Publication Date (W3CDTF): 2015-07-15
• Degree grantor/type: 三重大学
• Date Granted: 2015-07-15
• Date Granted (W3CDTF): 2015-07-15
• Dissertation Number: 乙医学第985号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 乙医学第985号
• Text Language Code: eng
• Alias of Author: チョウ, ジセン; 張, 尓泉
• Subject Heading: Hypoxia; Nitric oxide; Pulmonary hypertension; Retinoic acid
• Target Audience: 一般
• Note (General): application/pdf; Background: An earlier study showed that all-trans-retinoic acid (ATRA) prevents the development of monocrotalin-induced pulmonary hypertension (PH). The purpose of the present study was to determine the effect of ATRA on another model of chronic hypoxia-induced PH.Methods and Results: Male Sprague – Dawley rats were given 30 mg/kg ATRA or vehicle only by gavage once daily for 14 days during hypobaric hypoxic exposure. Chronic hypoxic exposure induced PH, right ventricular hypertrophy (RVH), and hypertensive pulmonary vascular changes. Quantitative morphometry of the pulmonary arteries showed that ATRA treatment significantly reduced the percentage of muscularized arteries in peripheral pulmonary arteries only with an external diameter between 15 and 50 μm. ATRA treatment also significantly reduced the medial wall thickness in small muscular arteries only with an external diameter between 50 and100 μm. Unfortunately, these reductions did not accompany the lowering of pulmonary artery pressure nor decrease in RVH. Chronic hypoxia-induced PH rats with ATRA had a loss in body weight. Chronic hypoxia increased the expression of endothelial nitric oxide synthase in the lung on western blotting and immunohistochemistry, in which ATRA treatment had no effect.Conclusions: The administration of ATRA might not have a therapeutic role in preventing the development of chronic hypoxia-induced PH, because of body weight loss and the subtle preventable effects of vascular changes.; 本文/Anesthesiology and Critical Care Medicine, Physiology, Pediatrics, Mie University School of Medicine; 8p
• DOI: info:doi/10.1253/circj.cj-10-0097; https://doi.org/info:doi/10.1253/circj.cj-10-0097
• Persistent ID (NDL): info:ndljp/pid/11526698; https://dl.ndl.go.jp/pid/11526698
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-08-11T22:41:34+09:00
• Date Created (W3CDTF): 2020-07-29
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10076/00019137; https://mie-u.repo.nii.ac.jp/records/13519
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2023-12-15 再収集