Relationships of Alpha- SMA-Positive Fibroblasts and SDF-1-Positive Tumor Cells with Neoangiogenesis in Nasopharyngeal Carcinoma

• Material Type: 博士論文
• Title: Relationships of Alpha- SMA-Positive Fibroblasts and SDF-1-Positive Tumor Cells with Neoangiogenesis in Nasopharyngeal Carcinoma
• Author/Editor: Wang, Shumin
• Author Heading: Wang, Shumin
• Publication, Distribution, etc.: 三重大学
• Publication Date: 2015-09-16
• Publication Date (W3CDTF): 2015-09-16
• Degree grantor/type: 三重大学
• Date Granted: 2015-09-16
• Date Granted (W3CDTF): 2015-09-16
• Dissertation Number: 甲医学第1744号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲医学第1744号
• Text Language Code: eng
• Alias of Author: ワン, シュミン; 王, 淑民
• Target Audience: 一般
• Note (General): application/pdf; Nasopharyngeal carcinoma (NPC) is one of the most prevalent malignant tumors with poor prognosis in Southern China and Southeast Asia. Angiogenesis-related molecules can be promising therapeutic targets in NPC. To investigate the relationships of cancer-associated fibroblasts (CAFs) and chemokine-related molecules with neoangiogenesis, we compared immunohistochemical analyses of alpha-smooth-muscle actin (α-SMA), stroma-derived factor-1 (SDF-1), and its receptor CXCR4 in primary NPC specimens and chronic nasopharyngitis tissues. In addition, we examined the expression of vascular endothelial growth factor(VEGF-A), and CD133- and VEGF- receptor-2 (VEGFR-2) double positive cells, as endothelial progenitor cells (EPCs). We also assessed CD34-positive microvessels. Significantly higher expression of α-SMA was observed in fibroblasts in NPC stroma. The immunoreactive intensities of SDF-1 and CXCR4 were significantly higher in NPC cells. CXCR4-positive cells and CD133/VEGFR-2- double positive cells were observed in the stroma surrounding cancer nests, and VEGF was detected in both cancer and stromal cells. Microvessel density was significantly higher in the stroma of NPC tissues compared to chronic nasopharyngitis tissues. Our data suggest that CAFs and NPC tumor cells may enhance neoangiogenesis in a VEGF- and SDF-1-dependent manner by recruiting EPCs from the bone marrow into tumor stroma.; 本文/Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine; 10p
• DOI: info:doi/10.1155/2014/507353; https://doi.org/info:doi/10.1155/2014/507353
• Persistent ID (NDL): info:ndljp/pid/11526699; https://dl.ndl.go.jp/pid/11526699
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-08-11T22:41:34+09:00
• Date Created (W3CDTF): 2020-07-29
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10076/00019138; https://mie-u.repo.nii.ac.jp/records/13520
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2023-12-15 再収集