Vascular Hyperintensity on Fluid-Attenuated Inversion Recovery Indicates the Severity of Hypoperfusion in Acute Stroke

• Material Type: 博士論文
• Title: Vascular Hyperintensity on Fluid-Attenuated Inversion Recovery Indicates the Severity of Hypoperfusion in Acute Stroke
• Author/Editor: Nomura, Toshiharu
• Publication Date: 2020-03-23
• Publication Date (W3CDTF): 2020-03-23
• Alternative Title: 急性期脳梗塞におけるFluid-attenuated inversion recovery (FLAIR) 画像上の血管高信号は灌流低下の重症度を反映する
• Degree grantor/type: 新潟大学
• Date Granted: 2020-03-23
• Date Granted (W3CDTF): 2020-03-23
• Dissertation Number: 甲第4670号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲第4670号
• Text Language Code: eng
• Subject Heading: Ischemic stroke; brain infarction; magnetic resonance imaging; magnetic resonance angiography; perfusion imaging
• Note (General): Background and Aim: Although fluid-attenuated inversion recovery vascular hyperintensities may be frequently seen in acute large-artery ischemic stroke, reports on their prognostic utility had been conflicting due to lack of quantitative evaluation of the perfusion status based on the signal intensity. We hypothesized that greater hyper intensity represents more severe hypoperfusion. Methods: Overall, 27 patients with acute occlusion of the proximal middle cerebral artery were divided into 2 groups, based on their signal intensity in the insular segment of middle cerebral artery on the affected side, relative to that of the insular cortex: the low signal intensity group (hypo- or isointense signals, n = 12) and the high signal intensity group (hyperintense signals, n = 15). Using dynamic susceptibility contrast magnetic resonance imaging, we assessed the time of the maximum value of the residue function and mean transit time, in the entire middle cerebral artery cortical area and diffusion-weighted imaging-Alberta Stroke Program Early Computed Tomography Score regions, including the corona radiata. Results: The high signal intensity group had significantly longer time of the maximum value of the residue function in all the diffusion-weighted imaging-Alberta Stroke Program Early Computed Tomography Score regions, except the M3 and M6 regions, and significantly longer mean transit time in the M1 and M4regions. Conclusions: Quantitative analysis of the perfusion parameters revealed more severely compromised and widely disturbed perfusion status in the high signal intensity group than in the low signal intensity group.; Journal of Stroke and Cerebrovascular Diseases. 2020, 29(2), 104467.; 新大院博(医)甲第904号; 元資料の権利情報 : 【○!C】 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license. (http://creativecommons.org/licenses/by-nc-nd/4.0/); 開始ページ : 1; 終了ページ : 8
• DOI: info:doi/10.1016/j.jstrokecerebrovasdis.2019.104467; https://doi.org/info:doi/10.1016/j.jstrokecerebrovasdis.2019.104467
• Persistent ID (NDL): info:ndljp/pid/11538603; https://dl.ndl.go.jp/pid/11538603
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• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-09-07T06:04:08+09:00
• Date Created (W3CDTF): 2020-08-31
• Format (IMT): application/pdf
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• Periodical Title (URI): http://hdl.handle.net/10191/00051793
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