Loss of autophagy impairs physiological steatosis by accumulation of NCoR1

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Loss of autophagy impairs physiological steatosis by accumulation of NCoR1

Persistent ID (NDL): info:ndljp/pid/11538604

Material type: 博士論文

Author: Takahashi, Shunsaku

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Date granted: 2020-03-23

Material Format: Digital

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Degree grantor and degree: 新潟大学,博士(医学)

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Note (General)：: Lipid droplets (LDs) are dynamic organelles that store neutral lipids during times of energy excess, such as after a meal. LDs serve as an energy rese...

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Material Type: 博士論文
Title: Loss of autophagy impairs physiological steatosis by accumulation of NCoR1
Author/Editor: Takahashi, Shunsaku
Publication Date: 2020-03-23
Publication Date (W3CDTF): 2020-03-23
Alternative Title: オートファジーの機能不全はNCoR1の蓄積により生理的脂肪肝を障害する
Degree Grantor: 新潟大学
Date Granted: 2020-03-23
Date Granted (W3CDTF): 2020-03-23
Dissertation Number: 甲第4672号
Degree Type: 博士(医学)
Conferring No. (Dissertation): 甲第4672号
Text Language Code: eng
Note (General): Lipid droplets (LDs) are dynamic organelles that store neutral lipids during times of energy excess, such as after a meal. LDs serve as an energy reservoir during fasting and have a buffering capacity that prevents lipotoxicity. Autophagy and the autophagic machinery have been proposed to play a role in LD biogenesis, but the underlying molecular mechanism remains unclear. Here, we show that when nuclear receptor co-repressor 1 (NCoR1), which inhibits the transactivation of nuclear receptors, accumulates because of autophagy suppression, LDs decrease in size and number. Ablation of ATG7, a gene essential for autophagy, suppressed the expression of gene targets of liver X receptor α, a nuclear receptor responsible for fatty acid and triglyceride synthesis in an NCoR1-dependent manner. LD accumulation in response to fasting and after hepatectomy was hampered by the suppression of autophagy. These results suggest that autophagy controls physiological hepatosteatosis by fine-tuning NCoR1 protein levels.
Life Science Alliance. 2020, 3(1), e201900513.
新大院博(医)甲第906号
元資料の権利情報 : 【○!C】 2019 Takahashi et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).
開始ページ : 1
終了ページ : 10
DOI: info:doi/10.26508/lsa.201900513
https://doi.org/info:doi/10.26508/lsa.201900513
Persistent ID (NDL): info:ndljp/pid/11538604
https://dl.ndl.go.jp/pid/11538604
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2020-09-07T06:04:08+09:00
Date Created (W3CDTF): 2020-08-31
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://hdl.handle.net/10191/00051795
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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