The neurocognitive function change criteria after whole-brain radiation therapy for brain metastasis, in reference to health-related quality of life changes : a prospective observation study : a prospective observation study

• Material Type: 博士論文
• Title: The neurocognitive function change criteria after whole-brain radiation therapy for brain metastasis, in reference to health-related quality of life changes : a prospective observation study : a prospective observation study
• Author/Editor: Nakano, Toshimichi
• Publication Date: 2020-03-23
• Publication Date (W3CDTF): 2020-03-23
• Alternative Title: 健康関連QOL変化を参考にした脳転移全脳照射後の認知機能変化
• Degree grantor/type: 新潟大学
• Date Granted: 2020-03-23
• Date Granted (W3CDTF): 2020-03-23
• Dissertation Number: 甲第4679号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲第4679号
• Text Language Code: eng
• Subject Heading: brain metastasis; health-related quality of life; neurocognitive function; whole brain radiation therapy
• Note (General): Background: We sought to construct the optimal neurocognitive function (NCF) change criteria sensitive to health-related quality of life (HR-QOL) in patients who have undergone whole-brain radiation therapy (WBRT) for brain metastasis. Methods: We categorized the patients by the changes of NCF into groups of improvement versus deterioration if at least one domain showed changes that exceeded the cut-off while other domains remained stable. The remaining patients were categorized as stable, and the patients who showed both significant improvement and deterioration were categorized as 'both.' We examined the clinical meaning of NCF changes using the cut-off values 1.0, 1.5, and 2.0SD based on the percentage of patients whose HR-QOL changes were ≥10 points. Results: Baseline, 4-month and 8-month data were available in 78, 41 (compliance; 85%), and 29 (81%) patients, respectively. At 4 months, improvement/stable/deterioration/both was seen in 15%/12%/41%/32% of the patients when 1.0 SD was used; 19%/22%/37%/22% with1.5 SD, and 17%/37%/37%/9% with 2.0 SD. The HR-QOL scores on the QLQ-C30 functional scale were significantly worse in the deterioration group versus the others with 1.0SD (p=0.013) and 1.5 SD (p=0.015). With 1.5 SD, the HR-QOL scores on the QLQ-BN20was significantly better in the improvement group versus the others (p=0.033). However, when 'both' was included in 'improvement' or 'deterioration,' no significant difference in HRQOL was detected. Conclusions: The NCF cut-off of 1.5 SD and the exclusion of 'both' patients from the 'deterioration' and 'improvement' groups best reflects HR-QOL changes.; BMC Cancer. 2020, 20(1), 66.; 新大院博(医)甲第913号
• DOI: info:doi/10.1186/s12885-020-6559-3; https://doi.org/info:doi/10.1186/s12885-020-6559-3
• Persistent ID (NDL): info:ndljp/pid/11538610; https://dl.ndl.go.jp/pid/11538610
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-09-07T06:04:08+09:00
• Date Created (W3CDTF): 2020-08-31
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10191/00051802
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp