Development of a mouse nerve-transfer model for brachial plexus injury

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Development of a mouse nerve-transfer model for brachial plexus injury

Persistent ID (NDL): info:ndljp/pid/11538621

Material type: 博士論文

Author: Wakatsuki, Hanako

Publisher: -

Publication date: 2020-03-23

Material Format: Digital

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Name of awarding university/degree: 新潟大学,博士(医学)

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Note (General)：: Nerve transfer involves the use of a portion of a healthy nerve to repair an injured nerve, and the　process has been used to alleviate traumatic brach...

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Material Type: 博士論文
Title: Development of a mouse nerve-transfer model for brachial plexus injury
Author/Editor: Wakatsuki, Hanako
Publication Date: 2020-03-23
Publication Date (W3CDTF): 2020-03-23
Alternative Title: 腕神経損傷に対するマウス神経移行術モデルの作成
Degree grantor/type: 新潟大学
Date Granted: 2020-03-23
Date Granted (W3CDTF): 2020-03-23
Dissertation Number: 甲第4695号
Degree Type: 博士(医学)
Conferring No. (Dissertation): 甲第4695号
Text Language Code: eng
Note (General): Nerve transfer involves the use of a portion of a healthy nerve to repair an injured nerve, and the　process has been used to alleviate traumatic brachial plexus injuries in humans. Study of the neural mechanisms that occur during nerve transfer, however, requires the establishment of reliable　experimental models. In this study, we developed an ulnar-musculocutaneous nerve-transfer model　wherein the biceps muscle of a mouse was re-innervated using a donor ulnar nerve. Similar muscle　action potentials were detected in both the end-to-end suture of the transected nerve (correct-repair) group and the ulnar-musculocutaneous nerve-transfer group. Also, re-innervated acetylcholine receptor (AChR) clusters and muscle spindles were observed in both procedures. There were　fewer re-innervated AChR clusters in the nerve transfer group than in the correct repair group at 4weeks, but the numbers were equal at 24 weeks following surgery. Thus, our ulnar-musculocutaneous nerve-transfer model allowed physiological and morphological evaluation for re-innervation　process in mice and revealed the delay of this process during nerve transfer procedure. This model will provide great opportunities to study regeneration, re-innervation, and functional recovery　induced via nerve transfer procedures.
Biomedical Research. 2019, 40(3), 115-123.
新大院博(医)甲第929号
DOI: info:doi/10.2220/biomedres.40.115
https://doi.org/info:doi/10.2220/biomedres.40.115
Persistent ID (NDL): info:ndljp/pid/11538621
https://dl.ndl.go.jp/pid/11538621
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2020-09-07T06:04:08+09:00
Date Created (W3CDTF): 2020-08-31
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://hdl.handle.net/10191/00051818
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp