Clinicopathological analysis of splenic red pulp low grade B-cell lymphoma

Persistent ID (NDL): info:ndljp/pid/11538633

Material type: 博士論文

Author: Suzuki, Takaharu

Publisher: -

Publication date: 2020-03-23

Material Format: Digital

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Name of awarding university/degree: 新潟大学,博士(医学)

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Note (General)：: Primary splenic low-grade B-cell lymphoma of the red pulp comprises hairy cell leukemia (HCL) and splenic B-cell lymphoma/leukemia, unclassifiable (SP...

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Material Type: 博士論文
Title: Clinicopathological analysis of splenic red pulp low grade B-cell lymphoma
Author/Editor: Suzuki, Takaharu
Publication Date: 2020-03-23
Publication Date (W3CDTF): 2020-03-23
Alternative Title: 脾臓赤脾髄原発低悪性度B細胞性リンパ腫の臨床病理学的解析
Degree grantor/type: 新潟大学
Date Granted: 2020-03-23
Date Granted (W3CDTF): 2020-03-23
Dissertation Number: 甲第4707号
Degree Type: 博士(医学)
Conferring No. (Dissertation): 甲第4707号
Text Language Code: eng
Subject Heading: Splenic B-cell lymphoma/leukemia
unclassifiable
Hairy cell leukemia-variant
BRAF mutation (V600E)
cyclin D3
cyclin D1
Note (General): Primary splenic low-grade B-cell lymphoma of the red pulp comprises hairy cell leukemia (HCL) and splenic B-cell lymphoma/leukemia, unclassifiable (SPLL-U). SPLL-U is a rare disease that includes subtypes of a hairy cell leukemia-variant (HCL-v), splenic diffuse red pulp small B-cell lymphoma (SDRPL), and other types that are known as narrow-sense SPLL-U (SPLL-U-NS). Notably, limited information is available regarding the BRAF mutation (V600E) and cyclin D3 expression in subtypes of SPLL-U. Therefore, we performed a pathological analysis of the BRAF mutation (V600E) and characterized pathological features of SPLL-U. We reviewed the pathological findings of 12 SPLL-U cases. The 12 cases considered included 2 cases of HCL-v, 6 cases of SPLLU-NS, and 4 undetermined cases. The BRAF mutation (V600E) was detected in 3 cases, which were all SPLL-U-NS. Cases with the BRAF mutation (V600E) have increased levels of CD103 expression and decreased cyclin D3 and cyclin D1 expression compared with cases that lacked the BRAF mutation. These findings suggest that the BRAF mutation might play a significant role in SPLL-U. Therefore, the significance of the BRAF mutation should be evaluated via genomic or transcriptional analyses of a large cohort of SPLL-U patients.
Pathology International. 2020, 70(5), 280-286.
新大院博(医)甲第941号
開始ページ : 1
終了ページ : 15
DOI: info:doi/10.1111/pin.12909
https://doi.org/info:doi/10.1111/pin.12909
Persistent ID (NDL): info:ndljp/pid/11538633
https://dl.ndl.go.jp/pid/11538633
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2020-09-07T06:04:08+09:00
Date Created (W3CDTF): 2020-08-31
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://hdl.handle.net/10191/00051830
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp