Risk of coronary artery disease according to glucose abnormality status and prior coronary artery disease in Japanese men

• Material Type: 博士論文
• Title: Risk of coronary artery disease according to glucose abnormality status and prior coronary artery disease in Japanese men
• Author/Editor: Kitazawa, Masaru
• Publication Date: 2020-03-23
• Publication Date (W3CDTF): 2020-03-23
• Alternative Title: 日本人男性における耐糖能障害と心血管疾患の既往がその後の心血管疾患発症へ与えるの影響の検討
• Degree grantor/type: 新潟大学
• Date Granted: 2020-03-23
• Date Granted (W3CDTF): 2020-03-23
• Dissertation Number: 甲第4714号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲第4714号
• Text Language Code: eng
• Subject Heading: Coronary artery disease; Glucose abnormality status; Clinical epidemiology; Cardiovascular disease; Risk factors
• Note (General): Objective: Although glucose abnormality status (GAS), prior coronary artery disease (CAD). , and other traditional risk factors affect the incidence of subsequent CAD, their impact in the same cohort has been scantly studied. Research design and methods: We analyzed data from a nationwide claims database in Japan that was accumulated during 2008–2016 involving 138,162 men aged 18–72 years. Participants were classified as having normoglycemia, borderline glycemia, or diabetes mellitus (DM) with prior CAD (CAD+) or without prior CAD (CAD−). Cox regression model identified variables related to the incidence of CAD. Results: Among CAD−, management of traditional risks differed from those with and without subsequent CAD events. On the other hand, such differences were weaker in borderline glycemia and DM CAD+, and the influence of traditional risk factors on subsequent CAD was not observed. Cox regression model showed that borderline glycemia and DM confer approximately 1.2- and 2.8-fold excess risks of CAD, respectively, compared with CAD− with normoglycemia. CAD+ confers approximately a 5- to 8-fold increased risk. The impacts of DM and prior CAD additively reached a hazard ratio (HR) of 15.74 (95% confidence interval [CI]: 11.82–21.00). However, the HR in those with borderline glycemia and CAD+ was 7.20 (95% CI: 5.01–10.34), which was not different from those with normoglycemia and CAD+. Conclusion: Control status of traditional risk factors and impact on subsequent CAD differ among categories of glycemic status with and without prior CAD. Individualizing treatment strategies is needed in consideration of risk factors, such as GAS and CAD+.; Metabolism Clinical and Experimental. 2019, 101, 153991.; 新大院博(医)甲第948号; 元資料の権利情報 : 【○!C】 2019 Elsevier Inc. All rights reserved.
• DOI: info:doi/10.1016/j.metabol.2019.153991; https://doi.org/info:doi/10.1016/j.metabol.2019.153991
• Persistent ID (NDL): info:ndljp/pid/11538640; https://dl.ndl.go.jp/pid/11538640
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-09-07T06:04:08+09:00
• Date Created (W3CDTF): 2020-08-31
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10191/00051837
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp