A pilot assessment of xanthine oxidase activity in plasma from patients with hematological malignancies using a highly sensitive assay

• Material Type: 博士論文
• ISSN: 0278-0232
• Title: A pilot assessment of xanthine oxidase activity in plasma from patients with hematological malignancies using a highly sensitive assay
• Volume: 37 4
• Author/Editor: Hokama, Noboru; 外間, 登
• Author Heading: Hokama, Noboru; 外間, 登
• Publication, Distribution, etc.: University of the Ryukyus
• Publication Date: 2019-07-29
• Publication Date (W3CDTF): 2019-07-29
• Periodical title: Hematological Oncology
• Degree grantor/type: 琉球大学
• Date Granted: 2020-03-24
• Date Granted (W3CDTF): 2020-03-24
• Dissertation Number: 甲第506号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 医研第506号
• Text Language Code: eng
• Subject Heading: xanthine oxidase (XO); graft-versus-host disease (GVHD); allogeneic hematopoietic stem cell transplantation (allo-HSCT); hematological malignancy; uric acid
• Target Audience: 一般
• Note (General): Xanthine oxidase (XO) is a rate limiting enzyme for production of uric acid. The activity of XO in plasma is reported to elevate in patients with familial hypercholesterolaemia and cardiovascular diseases. Such an increase in plasma XO activity was also demonstrated in patients with a variety of cancers. However, there have been few reports evaluating the plasma XO activity in patients with hematological malignancies during course of allogeneic hematopoietic stem cell transplantation (allo-HSCT) and chemotherapies. We explored the relationship between plasma XO activity and clinical symptoms/biochemical parameters in 10 patients with hematological malignancies. The XO activity was measured by a highsensitivity fluorescence technique. Plasma XO activity in hematological malignancies before chemotherapy was not elevated compared to healthy subjects. In patients receiving allo-HSCT, no apparent increase in plasma XO activity was observed at the appearance of graft-versus-host disease (GVHD). Noticeably, however, the value of plasma XO activity was closely associated with that of serum level of liver transaminases in the course of allo-HSCT and chemotherapies. To our knowledge, the present study is the first to investigate consecutively the value in plasma XO activity in patients with hematological malignancies. Despite small numbers analyzed, value of plasma XO activity was tightly associated with that of serum level of liver transaminases in the course of allo-HSCT and chemotherapies, suggesting that the value may reflect liver damage related with a variety of therapeutic interventions.; 学位論文
• DOI: info:doi/10.1002/hon.2659; https://doi.org/info:doi/10.1002/hon.2659
• Persistent ID (NDL): info:ndljp/pid/11551857; https://dl.ndl.go.jp/pid/11551857
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-10-06T21:18:06+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/20.500.12000/46669; https://u-ryukyu.repo.nii.ac.jp/records/2012591
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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