Estrogen receptor β controls muscle growth and regeneration in young female mice

• Material Type: 博士論文
• ISSN: 2213-6711
• Title: Estrogen receptor β controls muscle growth and regeneration in young female mice
• Volume: 15 3
• Author/Editor: 瀬古, 大暉
• Author Heading: 瀬古, 大暉
• Publication, Distribution, etc.: Cell Press
• Publication Date: 2020-09-02
• Publication Date (W3CDTF): 2020-09-02
• Alternative Title: エストロゲン受容体βは若齢雌マウスの筋成長と再生を制御する
• Periodical title: Stem Cell Reports
• Degree grantor/type: Nagasaki University (長崎大学)
• Date Granted: 2020-09-02
• Date Granted (W3CDTF): 2020-09-02
• Dissertation Number: 甲医歯薬第1268号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲医歯薬第1268号
• Text Language Code: eng
• Subject Heading: estrogen receptor β; estrogens; muscle mass; muscle growth; muscle regeneration; muscle stem cells
• Target Audience: 一般
• Note (General): Estrogens are female sex hormones that are important for comprehensively maintaining muscle function, and an insufficiency affects muscle strength and regeneration in females. However, it is still unclear whether estrogen signaling is mediated through receptors. To investigate the specific role of estrogen receptor β (ERβ) in skeletal muscle and satellite cells (muscle stem cells), we generated muscle-specific ERβ-knockout (mKO) and satellite cell-specific ERβ-knockout (scKO) mice, respectively. Young female mKO mice displayed a decrease in fast-type dominant muscle mass. Female, but not male, scKO mice exhibited impaired muscle regeneration following acute muscle injury, probably due to reduced proliferation and increased apoptosis of satellite cells. RNA-sequencing analysis revealed that loss of ERβ in satellite cells altered gene expression of extracellular matrix components, including laminin and collagen. The results indicate that the estrogen-ERβ pathway is a sex-specific regulatory mechanism that controls muscle growth and regeneration in female mice.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第1268号 学位授与年月日:令和2年9月2日; Author: Daiki Seko, Ryo Fujita, Yuriko Kitajima, Kodai Nakamura, Yuuki Imai, Yusuke Ono; Citation: Stem Cell Reports, 15(3), pp.577-586; 2020; identifier:Nagasaki University (長崎大学), 博士(医学) (2020-09-02); http://hdl.handle.net/10069/40338
• DOI: info:doi/10.1016/j.stemcr.2020.07.017; https://doi.org/info:doi/10.1016/j.stemcr.2020.07.017
• Persistent ID (NDL): info:ndljp/pid/11551963; https://dl.ndl.go.jp/pid/11551963
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-10-06T21:18:06+09:00
• Date Created (W3CDTF): 2020-12-16
• Format (IMT): PDF
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Related Material (URI): http://hdl.handle.net/10069/40338
• Periodical Title (URI): http://hdl.handle.net/10069/40276
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2021-03-07 再収集