Alternative Title低カルボキシル化オステオカルシン高値で評価されるビタミンK不足は女性において骨量低下と関連する
Periodical titleJournal of Physiological Anthropology
Degree grantor/typeNagasaki University (長崎大学)
Note (General)Background: An increase in serum undercarboxylated osteocalcin concentrations suggests vitamin K deficiency. Clinical intervention studies suggested that the vitamin K supplementation might contribute to preventing bone loss in postmenopausal women. Evidence on the relationship between serum undercarboxylated osteocalcin (ucOC) levels and bone parameters of quantitative ultrasound (QUS) is limited. We examined the correlation between serum ucOC concentrations and bone status as measured by QUS among middle-aged and older Japanese men and women. Methods: The subjects were community-dwelling men (n = 358) and women (n = 503) aged ? 40?years in Japan. Heel QUS parameters, including the stiffness index, speed of sound, and broadband ultrasound attenuation, were measured. Serum ucOC concentrations were measured by electrochemiluminescence immunoassay. Grip strength was measured in the dominant hand. Information on alcohol drinking, current smoking, exercise, and menopause in women was collected. Results: Serum ucOC concentrations were significantly associated with age in both sexes. Serum ucOC concentrations in men were higher at ? 80?years than those in the age groups of 40?49, 50?59, and 60?69?years. Serum ucOC concentrations in women were higher in the age groups of 50?59 and 60?69?years than those at 40?49?years. Partial correlation analysis adjusting for covariates (age, body mass index, grip strength, alcohol drinking, current smoking, and exercise in men; age, body mass index, grip strength, alcohol drinking, current smoking, exercise, and menopause in women) showed that serum ucOC concentrations were negatively significantly correlated with all QUS parameters in women. Serum ucOC concentrations were not correlated with them in men. Conclusions: Vitamin K deficiency, evaluated with higher serum ucOC, was correlated with poor bone status in women.
長崎大学学位論文 学位記番号:博(医歯薬)甲第1269号 学位授与年月日:令和2年9月2日
Author: Natsumi Tanaka, Kazuhiko Arima, Takayuki Nishimura, Yoshihito Tomita, Satoshi Mizukami, Takuhiro Okabe, Yasuyo Abe, Shin-ya Kawashiri, Michiko Uchiyama, Yuzo Honda, Ritsu Tsujimoto, Mitsuo Kanagae, Makoto Osaki & Kiyoshi Aoyagi
Citation: Journal of Physiological Anthropology, 39, art.no.9; 2020
identifier:Nagasaki University (長崎大学), 博士(医学) (2020-09-02)
http://hdl.handle.net/10069/40339
Collection (particular)国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
Date Accepted (W3CDTF)2020-10-06T21:18:06+09:00
Data Provider (Database)国立国会図書館 : 国立国会図書館デジタルコレクション