Reduction of stearoyl-CoA desaturase (SCD) contributes muscle atrophy through the excess endoplasmic reticulum stress in chronic kidney disease

• Material Type: 博士論文
• ISSN: 0912-0009
• Title: Reduction of stearoyl-CoA desaturase (SCD) contributes muscle atrophy through the excess endoplasmic reticulum stress in chronic kidney disease
• Volume: 67 2
• Author/Editor: Niida, Yuki; Masuda, Masashi; Adachi, Yuichiro; Yoshizawa, Aika; Ohminami, Hirokazu; Mori, Yuki; Ohnishi, Kohta; Yamanaka-Okumura, Hisami; Uchida, Takayuki; Nikawa, Takeshi; Yamamoto, Hironori; Miyazaki, Makoto; Taketani, Yutaka
• Author Heading: Niida, Yuki; Masuda, Masashi; Adachi, Yuichiro; Yoshizawa, Aika; Ohminami, Hirokazu; Mori, Yuki; Ohnishi, Kohta; Yamanaka-Okumura, Hisami; Uchida, Takayuki; Nikawa, Takeshi; Yamamoto, Hironori; Miyazaki, Makoto; Taketani, Yutaka
• Publication, Distribution, etc.: Society for Free Radical Research Japan
• Publication Date: 2020-09-01
• Publication Date (W3CDTF): 2020-09-01
• Alternative Title: stearoyl-CoA desaturaseの低下は慢性腎臓病における過剰な小胞体ストレスを介して筋萎縮に寄与する
• Periodical title: Journal of Clinical Biochemistry and Nutrition
• Degree grantor/type: 徳島大学
• Date Granted: 2020-03-23
• Date Granted (W3CDTF): 2020-03-23
• Dissertation Number: 甲第3419号
• Degree Type: 博士（栄養学）
• Conferring No. (Dissertation): 甲第3419号
• Text Language Code: eng
• Subject Heading: skeletal muscle atrophy; endoplasmic reticulum (ER) stress; chronic kidney disease (CKD); stearoyl-CoA desaturase (SCD); saturated fatty acid (SFA)
• Target Audience: 一般
• Note (General): Skeletal muscle atrophy is associated with mortality and poor prognosis in patients with chronic kidney disease (CKD). However, underlying mechanism by which CKD causes muscle atrophy has not been completely understood. The quality of lipids (lipoquality), which is defined as the functional features of diverse lipid species, has recently been recognized as the pathology of various diseases. In this study, we investigated the roles of the stearoyl-CoA desaturase (SCD), which catalyzes the conversion of saturated fatty acids into monounsaturated fatty acids, in skeletal muscle on muscle atrophy in CKD model animals. In comparison to control rats, CKD rats decreased the SCD activity and its gene expression in atrophic gastrocnemius muscle. Next, oleic acid blocked the reduction of the thickness of C2C12 myotubes and the increase of the endoplasmic reticulum stress induced by SCD inhibitor. Furthermore, endoplasmic reticulum stress inhibitor ameliorated CKD-induced muscle atrophy (the weakness of grip strength and the decrease of muscle fiber size of gastrocnemius muscle) in mice and the reduction of the thickness of C2C12 myotubes by SCD inhibitor. These results suggest that the repression of SCD activity causes muscle atrophy through excessive endoplasmic reticulum stress in CKD.
• DOI: info:doi/10.3164/jcbn.20-24; https://doi.org/info:doi/10.3164/jcbn.20-24
• Persistent ID (NDL): info:ndljp/pid/11569992; https://dl.ndl.go.jp/pid/11569992
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-11-10T19:58:22+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/114720
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp