Involvement of Receptor for Advanced Glycation Endproducts in Hypertensive Disorders of Pregnancy.

• Material Type: 博士論文
• ISSN: 1422-0067
• Title: Involvement of Receptor for Advanced Glycation Endproducts in Hypertensive Disorders of Pregnancy.
• Volume: 20 21
• Author/Editor: Akasaka, Juria; Naruse, Katsuhiko; Sado, Toshiyuki; Uchiyama, Tomoko; Makino, Mai; Yamauchi, Akiyo; Ota, Hiroyo; Sakuramoto-Tsuchida, Sumiyo; Itaya-Hironaka, Asako; Takasawa, Shin; Kobayashi, Hiroshi
• Author Heading: Akasaka, Juria; Naruse, Katsuhiko; Sado, Toshiyuki; Uchiyama, Tomoko; Makino, Mai; Yamauchi, Akiyo; Ota, Hiroyo; Sakuramoto-Tsuchida, Sumiyo; Itaya-Hironaka, Asako; Takasawa, Shin; Kobayashi, Hiroshi
• Publication, Distribution, etc.: MDPI
• Publication Date: 2019-11; 20 21
• Publication Date (W3CDTF): 2019-11
• Alternative Title: 妊娠高血圧症候群におけるRAGEの関与
• Periodical title: International journal of molecular sciences
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2020-03-16
• Date Granted (W3CDTF): 2020-03-16
• Dissertation Number: 乙第1451号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 乙第1451号
• Text Language Code: eng
• Subject Heading: hypertensive disorders of pregnancy; RAGE; AGE; adipocyte; IL-6; CCL2; LPS
• Target Audience: 一般
• Note (General): type:Thesis; Preeclampsia/hypertensive disorders of pregnancy (PE/HDP) is a serious and potentially life-threatening disease. Recently, PE/HDP has been considered to cause adipose tissue inflammation, but the detailed mechanism remains unknown. We exposed human primary cultured adipocytes with serum from PE/HDP and healthy controls for 24 h, and analyzed mRNA expression of several adipokines, cytokines, and ligands of the receptor for advanced glycation endproducts (RAGE). We found that the mRNA levels of interleukin-6 (IL-6), C-C motif chemokine ligand 2 (CCL2), high mobility group box 1 (HMGB1), and RAGE were significantly increased by the addition of PE/HDP serum. Among RAGE ligands, advanced glycation endproducts (AGE) and HMGB1 increased mRNA levels of IL-6 and CCL2 in SW872 human adipocytes and mouse 3T3-L1 cells. The introduction of small interfering RNA for RAGE (siRAGE) into SW872 cells abolished the AGE- and HMGB1-induced up-regulation of IL-6 and CCL2. In addition, lipopolysaccharide (LPS), a ligand of RAGE, increased the expression of IL-6 and CCL2 and siRAGE attenuated the LPS-induced expression of IL-6 and CCL2. These results strongly suggest that the elevated AGE, HMGB1, and LPS in pregnant women up-regulate the expression of IL-6 and CCL2 via the RAGE system, leading to systemic inflammation such as PE/HDP.; 博士（医学）・乙第1451号・令和2年3月16日; © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).; identifier:International journal of molecular sciences Vol.20 No.21 Article No.5462 (2019 Nov); identifier:14220067; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3741; identifier:International journal of molecular sciences, 20(21): Article No.5462
• DOI: info:doi/10.3390/ijms20215462; https://doi.org/info:doi/10.3390/ijms20215462
• Persistent ID (NDL): info:ndljp/pid/11570073; https://dl.ndl.go.jp/pid/11570073
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-11-10T19:58:22+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10564/3741
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

Table of Contents

2024-05-04 再収集

2024-05-04 再収集

2024-05-04 再収集