Urinary Nerve Growth Factor Can Predict Therapeutic Efficacy in Children With Overactive Bladder.

• Material Type: 博士論文
• ISSN: 0090-4295
• Title: Urinary Nerve Growth Factor Can Predict Therapeutic Efficacy in Children With Overactive Bladder.
• Volume: 103
• Author/Editor: Fukui, Shinji; Aoki, Katsuya; Morizawa, Yosuke; Miyake, Makito; Fujimoto, Kiyohide
• Author Heading: Fukui, Shinji; Aoki, Katsuya; Morizawa, Yosuke; Miyake, Makito; Fujimoto, Kiyohide
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2017-05; 103
• Publication Date (W3CDTF): 2017-05
• Alternative Title: 尿中Nerve Growth Factorは、過活動膀胱症状を呈する患児の治療効果の予測因子になる
• Periodical title: Urology
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2020-03-16
• Date Granted (W3CDTF): 2020-03-16
• Dissertation Number: 乙第1454号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 乙第1454号
• Text Language Code: eng
• Target Audience: 一般
• Note (General): type:Thesis; Objective: To assess urinary nerve growth factor (NGF) in children with overactive bladder (OAB) and to investigate the relationship between urinary NGF/creatinine (Cr) levels and OAB. Patients and methods: Thirty-five children (27 boys and 8 girls) with OAB and 11 children (6 boys and 5 girls) without OAB or any other urinary symptoms, who served as controls, were included in this study. Urinary NGF levels were measured using enzyme-linked immunosorbent assay. The total urinary NGF levels were adjusted with the concentration of urinary creatinine (NGF/Cr level). Refractory OAB was defined as little improvement in OAB symptoms despite at least 3 months of urotherapy and anticholinergic agent treatment. Urinary NGF/Cr was compared between the children with OAB and the controls. The relationship between urinary NGF/Cr and treatment outcomes was also evaluated. Results: Urinary NGF/Cr was significantly higher in the children with OAB when compared with those in the control group (0.65 ± 0.82 vs 0.11 ± 0.09, P = .0007). Improvement of OAB symptoms was observed in 26 out of 35 children (74%). The remaining 9 children showed refractory OAB symptoms (the refractory group). Urinary NGF/Cr was significantly higher in the refractory group than in the improved group (1.28 ± 1.34 vs 0.44 ± 0.39, P = .027). Conclusion: Urinary NGF/Cr was significantly higher in the children with OAB than in the controls, and was significantly higher in the refractory group than in the improved group. Urinary NGF/Cr could not only be a potential biomarker for children with OAB, but also a predictor of therapeutic efficacy in children with OAB.; 博士（医学）・乙第1454号・令和2年3月16日; Copyright © 2017 Elsevier Inc. All rights reserved.; identifier:Urology Vol.103 p.214-217 (2017 May); identifier:00904295; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3744; identifier:Urology, 103: 214-217
• DOI: info:doi/10.1016/j.urology.2017.01.021; https://doi.org/info:doi/10.1016/j.urology.2017.01.021
• Persistent ID (NDL): info:ndljp/pid/11570075; https://dl.ndl.go.jp/pid/11570075
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-11-10T19:58:22+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10564/3744
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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