D-Tagatose Effectively Reduces the Number of Streptococcus mutans and Oral Bacteria in Healthy Adult Subjects : a Chewing gum Pilot Study and Randomized Clinical Trial

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DOI[info:doi/10.18926/AMO/60369]to the data of the same series

D-Tagatose Effectively Reduces the Number of Streptococcus mutans and Oral Bacteria in Healthy Adult Subjects : a Chewing gum Pilot Study and Randomized Clinical Trial

Persistent ID (NDL): info:ndljp/pid/11570358

Material type: 博士論文

Author: 永峰, 優一

Publisher: -

Publication date: 2020-09-29

Material Format: Digital

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Name of awarding university/degree: 香川大学,博士（医学）

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Note (General)：: We examined the effect of D-Tagatose on the growth of oral bacteria including Streptococcus mutans (S. mutans). Saliva collected from 10 healthy volun...

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Material Type: 博士論文
Title: D-Tagatose Effectively Reduces the Number of Streptococcus mutans and Oral Bacteria in Healthy Adult Subjects : a Chewing gum Pilot Study and Randomized Clinical Trial
Author/Editor: 永峰, 優一
Author Heading: 永峰, 優一
Publication Date: 2020-09-29
Publication Date (W3CDTF): 2020-09-29
Alternative Title: D-タガトースは Streptococcus mutans や口腔内細菌数を著明に抑制する : 健常な成人でのガムを用いた二重盲検法試験より
Degree grantor/type: 香川大学
Date Granted: 2020-09-29
Date Granted (W3CDTF): 2020-09-29
Dissertation Number: 甲第756号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第756号
Text Language Code: eng
Alias of Author: Nagamine, Yuichi
Subject Heading: D-Tagatose
Streptococcus mutans
chewing gum
oral bacteria
xylitol
Target Audience: 一般
Note (General): We examined the effect of D-Tagatose on the growth of oral bacteria including Streptococcus mutans (S. mutans). Saliva collected from 10 healthy volunteers was plated on BHI medium (to culture total oral bacteria) and MBS medium (to culture S. mutans, specifically). Agar plates of BHI or MBS containing xylitol or D-Tagatose were cultured under aerobic or anaerobic conditions. We then counted the number of colonies. In BHI plates containing D-Tagatose, a complete and significant reduction of bacteria occurred under both aerobic and anaerobic conditions. In MSB medium, significant reduction of S. mutans was also observed. We then performed a doubleblind parallel randomized trial with 19 healthy volunteers. They chewed gum containing xylitol, D-Tagatose, or both for 4 weeks, and their saliva was collected weekly and plated on BHI and MSB media. These plates were cultured under anaerobic conditions. Total bacteria and S. mutans were not effectively reduced in either the D-Tagatose or xylitol gum group. However, S. mutans was significantly reduced in volunteers chewing gum containing both D-Tagatose and xylitol. Thus, D-Tagatose inhibited the growth of S. mutans and many types of oral bacteria, indicating that D-Tagatose intake may help prevent dental caries, periodontitis, and many oral diseases.
DOI: info:doi/10.18926/AMO/60369
https://doi.org/info:doi/10.18926/AMO/60369
Persistent ID (NDL): info:ndljp/pid/11570358
https://dl.ndl.go.jp/pid/11570358
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2020-11-10T19:58:22+09:00
Date Created (W3CDTF): 2020-10-20
Format (IMT): PDF
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): https://kagawa-u.repo.nii.ac.jp/records/156
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp