Innate Immune Responses in Serum and Cerebrospinal Fluid From Neonates and Infants Infected With Parechovirus-A3 or Enteroviruses

• Material Type: 博士論文
• Title: Innate Immune Responses in Serum and Cerebrospinal Fluid From Neonates and Infants Infected With Parechovirus-A3 or Enteroviruses
• Author/Editor: Habuka, Rie
• Publication Date: 2020-09-23
• Publication Date (W3CDTF): 2020-09-23
• Alternative Title: パレコウイルスA3とエンテロウイルスに感染した新生児・早期乳児の血清・髄液中の自然免疫反応
• Degree grantor/type: 新潟大学
• Date Granted: 2020-09-23
• Date Granted (W3CDTF): 2020-09-23
• Dissertation Number: 甲第4797号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲第4797号
• Text Language Code: eng
• Note (General): Background. Parechovirus (PeV)-A3 and enteroviruses (EV) are the most common viruses causing sepsis and meningoencephalitis in neonates and young infants. Clinical manifestations of PeV-A3 infection are more severe than those of EV infection, and no pleocytosis with a positive polymerase chain reaction (PCR) result for PeV-A3 in cerebrospinal fluid (CSF) are characteristic findings. We hypothesized that innate immune responses to PeV-A3 and EV are distinct in serum and CSF. Methods. We evaluated 22 cytokines/chemokines in serum and CSF from PeV-A3- or EV-infected patients younger than 4 months in Niigata, Japan, from 2015 through 2018. Infection was diagnosed with real-time PCR followed by sequencing. Febrile neonates and infants with sepsis-like syndrome who had negative bacterial culture and viral PCR for both PeV-A and EV were also included (non-PeV-A/EV patients). Results. Among 192 febrile patients, we evaluated 16 PeV-A3-infected, 15 EV-infected, and 8 non-PeV-A/EV patients. Serum pro-/anti-inflammatory cytokine/chemokine levels were higher in PeV-A3-infected patients than in EV-infected patients (P < .02). Although most cytokine/chemokine were elevated in CSF from EV-infected patients, levels were low or undetectable in PeV-A3- infected and non-PeV-A/EV patients (P < .001). Conclusions. Distinct cytokine/chemokine patterns in serum and CSF may explain the different clinical manifestations of PeVA3-infected and EV-infected neonates and young infants.; The Journal of Infectious Diseases. 2020, 222(4), 681–689.; 新大院博(医)甲第967号; 元資料の権利情報 : 【○!C】 The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.
• DOI: info:doi/10.1093/infdis/jiaa131; https://doi.org/info:doi/10.1093/infdis/jiaa131
• Persistent ID (NDL): info:ndljp/pid/11583369; https://dl.ndl.go.jp/pid/11583369
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• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2020-12-08T06:37:43+09:00
• Date Created (W3CDTF): 2020-11-12
• Format (IMT): application/pdf
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• Periodical Title (URI): http://hdl.handle.net/10191/00051958
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp