Establishment of Cyclodextrin-based Hyperbranched Nanoparticles for Delivering Alpha Mangostin in Cancer Treatment

• Material Type: 博士論文
• Title: Establishment of Cyclodextrin-based Hyperbranched Nanoparticles for Delivering Alpha Mangostin in Cancer Treatment
• Author/Editor: ドアン ティ, ホン ヴァン
• Author Heading: ドアン ティ, ホン ヴァン
• Publication Date: 2020-09-26
• Publication Date (W3CDTF): 2020-09-26
• Alternative Title: シクロデキストリン架橋ナノ粒子を用いたアルファーマンゴスチンのがん細胞へのデリバリー
• Degree grantor/type: 北九州市立大学
• Date Granted: 2020-09-26
• Date Granted (W3CDTF): 2020-09-26
• Dissertation Number: 甲第145号
• Degree Type: 博士（工学）
• Conferring No. (Dissertation): 甲第145号
• Text Language Code: eng
• Subject Heading: Cyclodextrin; Alpha mangostin; Hyperbranched polymers; Drug Delivery System; Cancer treatment
• Target Audience: 一般
• Note (General): Alpha mangostin (MGS) is a natural xanthonoid compound isolated from a tropical fruit named Mangosteen. It is highly expected as a candidate of anticancer drugs. However, its highly hydrophobic and small molecule limit on applying clinical use. To use MGS in practice, it is needed to develop a suitable drug delivery system. Cyclodextrins (CDs) are biocompatible molecules approved by FDA as the material that can be injected into the human body and have already been used for a long time. The main advantage of CD comes from its hydrophilic exterior and hydrophobic interior of cavity. Thus, CD can encapsulate hydrophobic compounds like MGS to from complex, then that complex can stay in aqueous solution. The aim of thesis is to establish CD-based nanoparticles (CDNPs) for purpose of delivering MGS effectively in cancer treatment. CDNPs were prepared by use of polyaddition reaction with epichlorohydrin. Particle properties of CDNPs were controlled by changing weight ratio of the composition in reaction. Our CDNPs have a great loading ratio of MGS in comparison with native CDs. Additionally, CDNPs containing MGS has anticancer effect on both in vitro and in vivo experiment.
• Persistent ID (NDL): info:ndljp/pid/11629755; https://dl.ndl.go.jp/pid/11629755
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2021-01-30T08:56:55+09:00
• Date Created (W3CDTF): 2020-12-24
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): https://kitakyu.repo.nii.ac.jp/records/773
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2023-09-08 再収集