Studies on the multi-biological functions of α-mangostin including inhibition of cancer metastasis, reduction of cell stiffness and activation of leukocytes

• Material Type: 博士論文
• Title: Studies on the multi-biological functions of α-mangostin including inhibition of cancer metastasis, reduction of cell stiffness and activation of leukocytes
• Author/Editor: ファン ティ, キィウ チャン
• Author Heading: ファン ティ, キィウ チャン
• Publication Date: 2020-09-26
• Publication Date (W3CDTF): 2020-09-26
• Alternative Title: α-マンゴスチンの生物学的機能－がん浸潤抑制、細胞の機械特性低下、白血球の活性化―に関する研究
• Degree grantor/type: 北九州市立大学
• Date Granted: 2020-09-26
• Date Granted (W3CDTF): 2020-09-26
• Dissertation Number: 甲第146号
• Degree Type: 博士（工学）
• Conferring No. (Dissertation): 甲第146号
• Text Language Code: eng
• Subject Heading: α-Mangostin; Co-culture; Cancer invasion; Cell mechanics; Cytotoxicity; Atomic force microscopy; Actin cytoskeleton; Cell adhesion; Leukocyte
• Target Audience: 一般
• Note (General): In this research, it was made clear that α-Mangostin presented its diversified biological functions, it was not only found with anti-cancer, but also has other effects with different cell types. The anti-metastasis of α-Mangostin has been found in several researches on cancer cells, but in this study, I found that α-Mangostin also had positive effect on normal cells which were surrounded cancer cells. This finding is important to optimize the conditions of this compound as a chemotherapeutic and chemopreventive agent for cancer treatment. In addition, α-Mangostin changed the mechanical properties which has been proposed to participate in regulation of cell state and fate. The mechanical properies is also play important role in leukocytes, α-Mangostin reduced the cell stiffness followed by induced the cell adhesion and activated leukocytes. These results contribute to complete the whole picture of the biological function of α-Mangostin, and these functions of α-Mangostin are useful for studies on the potential pharmacological principles as well as the preclinical applications of the α-Mangostin.
• Persistent ID (NDL): info:ndljp/pid/11629756; https://dl.ndl.go.jp/pid/11629756
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2021-01-30T08:56:55+09:00
• Date Created (W3CDTF): 2020-12-24
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): https://kitakyu.repo.nii.ac.jp/records/774
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2023-09-08 再収集