The effect of gemcitabine on cell cycle arrest and microRNA signatures in pancreatic cancer cells

Persistent ID (NDL): info:ndljp/pid/11645616

Material type: 博士論文

Author: 波間, 大輔

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Publication date: 2020-12-24

Material Format: Digital

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Name of awarding university/degree: 香川大学,博士（医学）

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Note (General)：: Background/aim: Gemcitabine, an inhibitor of DNA synthesis, is the gold standard chemotherapeutic agent for pancreatic ductal adenocarcinoma (PDAC). M...

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Material Type: 博士論文
Title: The effect of gemcitabine on cell cycle arrest and microRNA signatures in pancreatic cancer cells
Author/Editor: 波間, 大輔
Author Heading: 波間, 大輔
Publication Date: 2020-12-24
Publication Date (W3CDTF): 2020-12-24
Alternative Title: 膵臓癌細胞の細胞周期停止およびmicroRNAシグネチャーに及ぼすゲムシタビンの効果
Degree grantor/type: 香川大学
Date Granted: 2020-12-24
Date Granted (W3CDTF): 2020-12-24
Dissertation Number: 甲第759号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第759号
Text Language Code: eng
Alias of Author: Namima, Daisuke
Subject Heading: Pancreatic neoplasm
cell cycle
cyclin
gemcitabine
microRNA
Target Audience: 一般
Note (General): Background/aim: Gemcitabine, an inhibitor of DNA synthesis, is the gold standard chemotherapeutic agent for pancreatic ductal adenocarcinoma (PDAC). MicroRNAs (miRNAs) play critical roles in cancers, including PDAC. However, less is known about the effect of gemcitabine on PDAC cells and miRNA expression in PDAC. We evaluated the effect of gemcitabine on the cell cycle of PDAC cells in vitro and in vivo and on the miRNA expression profile.
Materials and methods: Effects of gemcitabine on PK-1 and PK-9 cell growth were evaluated using a cell counting kit-8 assay. Xenografted mouse models were used to assess gemcitabine effects in vivo.
Results: Gemcitabine inhibited the proliferation and tumour growth of PK-1 cells, and induced S phase cell cycle arrest. Numerous miRNAs were altered upon gemcitabine treatment of PK-1 cells and xenograft models.
Conclusion: Altered miRNAs may serve as potential therapeutic targets for improving the efficacy of gemcitabine in PDAC.
DOI: info:doi/10.21873/invivo.12155
https://doi.org/info:doi/10.21873/invivo.12155
Persistent ID (NDL): info:ndljp/pid/11645616
https://dl.ndl.go.jp/pid/11645616
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2021-03-07T02:10:05+09:00
Date Created (W3CDTF): 2021-02-03
Format (IMT): PDF
Access Restrictions: 国立国会図書館内限定公開
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Availability of remote photoduplication service: 可
Periodical Title (URI): https://kagawa-u.repo.nii.ac.jp/records/7184
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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