Viral Etiology of Acute Lower Respiratory Tract Infections in Hospitalized Children in Nagasaki, a Regional City of Japan in 2013-2015

• Material Type: 博士論文
• ISSN: 0891-3668
• Title: Viral Etiology of Acute Lower Respiratory Tract Infections in Hospitalized Children in Nagasaki, a Regional City of Japan in 2013-2015
• Volume: 39 8
• Author/Editor: 蓮把, 朋之
• Author Heading: 蓮把, 朋之
• Publication, Distribution, etc.: Wolters Kluwer Health, Inc.
• Publication Date: 2020-06-03
• Publication Date (W3CDTF): 2020-06-03
• Alternative Title: 2013-2015年日本の地方都市長崎市における急性下気道感染症入院患児の原因ウイルスの解析
• Periodical title: Pediatric Infectious Disease Journal
• Degree grantor/type: Nagasaki University (長崎大学)
• Date Granted: 2020-06-03
• Date Granted (W3CDTF): 2020-06-03
• Dissertation Number: 甲医歯薬第1263号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲医歯薬第1263号
• Text Language Code: eng
• Subject Heading: acute lower respiratory tract infections; respiratory pathogens; epidemiology; multiplex polymerase chain reaction; enterovirus D68
• Target Audience: 一般
• Note (General): Background: Acute lower respiratory tract infections (ALRIs) are the most common disease for hospitalized children in Japan. The aim of this study was to identify viruses in children hospitalized for ALRIs and to demonstrate epidemiologic and clinical characteristics in Japan. Methods: During a 2-year period from February 2013 to January 2015, we collected nasopharyngeal swab specimens from almost all hospitalized children with ALRIs in Nagasaki, a regional city of Japan, and its environs. Viruses were detected by multiplex polymerase chain reaction from these samples. Results: We detected one or more viruses from 259 (69%) of 374 patients, 227 of whom were infected with a single virus, 30 with 2, and 2 with 3 viruses. Detected viruses in this study were rhinovirus (46.4%), respiratory syncytial virus (29.7%), human metapneumovirus (6.8%), parainfluenza virus (5.5%), enterovirus D68 (3.4%), influenza virus (2.7%), adenovirus (2.4%), bocavirus (2.0%) and Coxsackie virus (1.0%). We detected a seasonal shift in respiratory syncytial virus outbreaks from the 2013?2014 to the 2014?2015 seasons. There was no significant difference in clinical course and severity among those viruses. Patients with a history of asthma or underlying diseases were older and more frequently required oxygen therapy than previously healthy patients. Conclusions: Viral etiology in hospitalized children with ALRIs in Nagasaki, Japan, was similar to that in many other countries. Enterovirus D68, which was recently recognized as a causative agent of severe ALRIs, was also identified in this study area. Severity of ALRIs may depend on underlying disease rather than type of etiologic virus.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第1263号 学位授与年月日:令和2年6月3日; Author: Hasuwa, Tomoyuki; Kinoshita, Fumiko; Harada, Sadatomo; Nakashima, Kazuhisa; Yoshihara, Keisuke; Toku, Yuichirou; Moriuchi, Hiroyuki; Yoshida, Lay Myint; Citation: Pediatric Infectious Disease Journal, 39(8), pp.687-693; 2020; identifier:Nagasaki University (長崎大学), 博士(医学) (2020-06-03); http://hdl.handle.net/10069/40090
• DOI: info:doi/10.1097/INF.0000000000002668; https://doi.org/info:doi/10.1097/INF.0000000000002668
• Persistent ID (NDL): info:ndljp/pid/11659489; https://dl.ndl.go.jp/pid/11659489
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2021-04-07T03:01:57+09:00
• Date Created (W3CDTF): 2020-12-18
• Format (IMT): PDF
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Related Material (URI): http://hdl.handle.net/10069/40090
• Periodical Title (URI): http://hdl.handle.net/10069/40221
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp