Alternative Titleアルツハイマー病における不快表情認知と鉤状束との関連：横断的拡散テンソル画像研究
Note (General)type:Thesis
Background: Recognising facial emotions involves visual and emotional information processing. Patients with dementia, including dementia of Alzheimer's type (DAT), are known to poorly recognise facial emotions, especially negative facial emotions. In this study, we aimed to assess if DAT patients exhibit poor facial emotional recognition, and to identify a neural basis for how poor facial emotional recognition might occur. Methods: Magnetic resonance imaging and diffusion tensor imaging (DTI) analysis were conducted in 20 DAT patients and 15 cognitive normal (CN) subjects. The uncinate fasciculus (UF), inferior longitudinal fasciculus, and inferior fronto-occipital fasciculus were delineated by deterministic tractography. DTI parameters were calculated for each fibre. Facial emotion recognition was evaluated with the Facial Emotion Selection Test (FEST). The relationships between FEST scores and DTI parameters in each fibre were measured by partial correlation analyses with age, gender, and the Mini-Mental State Examination as covariates. Group-wise comparisons between DAT and CN subjects were performed for each DTI parameter in each fibre. Results: DAT patients showed lower FEST negative emotion scores than CN subjects (P < 0.05). The score of negative emotion subscale was negatively correlated (r = -0.770, P < 0.001) to mean diffusivity of the left UF in DAT patients. There were no relationships between negative emotion subscale and the other fibre tracts. DAT patients showed no differences in the DTI parameters for each fibre compared to CN subjects. Conclusions: DAT-related prefrontal-limbic network dysfunction is associated with poor recognition of unpleasant emotions; consequently, worse facial recognition of negative emotion is observed in DAT patients.
博士（医学）・甲第763号・令和2年12月24日
© 2020 Japanese Psychogeriatric Society
This is the peer reviewed version of the following article: https://onlinelibrary.wiley.com/doi/full/10.1111/psyg.12498, which has been published in final form at https://doi.org/10.1111/psyg.12498. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
identifier:Psychogeriatrics Vol.20 No.3 p.296-303 (2020 May)
identifier:13463500
identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3821
identifier:Psychogeriatrics, 20(3): 296-303
Collection (particular)国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
Date Accepted (W3CDTF)2021-04-07T03:01:57+09:00
Data Provider (Database)国立国会図書館 : 国立国会図書館デジタルコレクション