Capillary-resident EphA7+ pericytes are multipotent cells with anti-ischemic effects through capillary formation （EphA7陽性毛細血管周細胞は多分化能を有し、血管形成能を介して、組織虚血を改善する）

Persistent ID (NDL): info:ndljp/pid/11671516

Material type: 博士論文

Author: 吉田, 有里

Publisher: -

Publication date: 2020-01

Material Format: Digital

Capacity, size, etc.: -

Name of awarding university/degree: 旭川医科大学,博士（医学）

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Note (General)：: The presence of pericytes (PCs) with multipotency and broad distribution along capillary suggests that microvasculature plays a role not only as a duc...

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Material Type: 博士論文
ISSN: 2157-6564
Title: Capillary-resident EphA7+ pericytes are multipotent cells with anti-ischemic effects through capillary formation （EphA7陽性毛細血管周細胞は多分化能を有し、血管形成能を介して、組織虚血を改善する）
Volume: 9 1
Author/Editor: 吉田, 有里
Publication Date: 2020-01
Publication Date (W3CDTF): 2020-01
Periodical title: Stem cells translational medicine
Degree grantor/type: 旭川医科大学
Date Granted: 2020-03-25
Date Granted (W3CDTF): 2020-03-25
Dissertation Number: 甲第546号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第546号
Text Language Code: eng
Subject Heading: angiogenesis
capillary
mesenchymal stem cells
neuronal stem cells
pericytes
peripheral ischemic diseases.
Note (General): The presence of pericytes (PCs) with multipotency and broad distribution along capillary suggests that microvasculature plays a role not only as a duct for blood fluid transport but also as a stem cell niche that contributes to tissue maintenance and regeneration. The lack of an appropriate marker for multipotent PCs still limits our understanding of their pathophysiological roles. We identified the novel marker EphA7 to detect multipotent PCs using microarray analysis of an immortalized PC library. PCs were isolated from microvessels of mouse subcutaneous adipose tissues, then EphA7+ PCs called capillary stem cells (CapSCs) were separated from EphA7- control PCs (ctPCs) using fluorescence-activated cell sorting system. CapSCs had highly multipotency that enabled them to differentiate into mesenchymal and neuronal lineages compared with ctPCs. CapSCs also differentiated into endothelial cells and PCs to form capillary-like structures by themselves. Transplantation of CapSCs into ischemic tissues significantly improved blood flow recovery in hind limb ischemia mouse model due to vascular formation compared with that of ctPCs and adipose stromal cells. These data demonstrate that EphA7 identifies a subpopulation of multipotent PCs that have high angiogenesis and regenerative potency and are an attractive target for regenerative therapies.
identifier:PMID: 31471947
開始ページ : 120
終了ページ : 130
DOI: info:doi/10.1002/sctm.19-0148
https://doi.org/info:doi/10.1002/sctm.19-0148
Persistent ID (NDL): info:ndljp/pid/11671516
https://dl.ndl.go.jp/pid/11671516
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2021-05-16T23:51:55+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://amcor.asahikawa-med.ac.jp/modules/xoonips/detail.php?id=20200325_K546
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp