Diagnostic significance of apical membranous and cytoplasmic dot-like CD26 expression in encapsulated follicular variant of papillary thyroid carcinoma : a useful marker for capsular invasion

Persistent ID (NDL): info:ndljp/pid/11671728

Material type: 博士論文

Author: 髙木, 翔士

Publisher: -

Publication date: 2021-03-24

Material Format: Digital

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Name of awarding university/degree: 香川大学,博士（医学）

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Note (General)：: Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and invasive encapsulated follicular variant of papillary thyroi...

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Material Type: 博士論文
Title: Diagnostic significance of apical membranous and cytoplasmic dot-like CD26 expression in encapsulated follicular variant of papillary thyroid carcinoma : a useful marker for capsular invasion
Author/Editor: 髙木, 翔士
Author Heading: 髙木, 翔士
Publication Date: 2021-03-24
Publication Date (W3CDTF): 2021-03-24
Alternative Title: 被包性濾胞型乳頭癌におけるCD26の細胞膜発現およびドット状発現の診断意義 : 被膜浸潤の有用なマーカー
Degree grantor/type: 香川大学
Date Granted: 2021-03-24
Date Granted (W3CDTF): 2021-03-24
Dissertation Number: 甲第769号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第769号
Text Language Code: eng
Alias of Author: Takagi, Shoji
Subject Heading: Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)
Follicular variant of papillary thyroid carcinoma
CD26
Capsular invasion
Target Audience: 一般
Note (General): Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and invasive encapsulated follicular variant of papillary thyroid carcinoma (EFV-PTC) are indistinguishable preoperatively. CD26 expression in follicular tumor-uncertain malignant potential (FT-UMP) is reported to be clearly higher than in that without capsular invasion. To verify the diagnostic significance of CD26 immunostaining in EFV-PTC, we examined the expression pattern of CD26 in non-invasive EFV-PTC (NIFTP) and invasive EFV-PTC. We performed immunohistochemical analysis using CD26 antibody for 37 NIFTPs and 54 EFV-PTCs (34 minimally invasive EFV-PTCs and 20 widely invasive EFV-PTCs). Most NIFTP samples showed an apical membranous pattern or a cytoplasmic diffuse pattern of expression. Invasive EFV-PTCs more frequently showed a cytoplasmic dot-like pattern, and the labeling indices of tumor cells with cytoplasmic dot-like patterns were significantly higher than those in NIFTPs. The sizes of dots seen in NIFTPs (mean: 1.12 μm) were significantly smaller than in invasive EFV-PTCs (1.33 μm), minimally invasive EFV-PTC (1.27 μm), and widely invasive EFV-PTC (1.38 μm). We, therefore, conclude that cytoplasmic diffuse and/or cytoplasmic dot-like CD26 expression, particularly the larger CD26-positive dots, could be useful markers for capsular invasion in EFV-PTC. CD26 immunostaining, using cell blocks or cytological specimens, may preoperatively distinguish between NIFTP and invasive EFV-PTC.
DOI: info:doi/10.1507/endocrj.EJ19-0501
https://doi.org/info:doi/10.1507/endocrj.EJ19-0501
Persistent ID (NDL): info:ndljp/pid/11671728
https://dl.ndl.go.jp/pid/11671728
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2021-05-16T23:51:55+09:00
Date Created (W3CDTF): 2021-04-22
Format (IMT): PDF
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): https://kagawa-u.repo.nii.ac.jp/records/7335
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp