Immunoreactivities for hepcidin, ferroportin, and hephaestin in astrocytes and choroid plexus epithelium of human brains

Persistent ID (NDL): info:ndljp/pid/11671732

Material type: 博士論文

Author: 簗瀬, 賢

Publisher: -

Publication date: 2021-03-24

Material Format: Digital

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Name of awarding university/degree: 香川大学,博士（医学）

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Note (General)：: Iron plays essential roles in the central nervous system. However, how the iron level is regulated in brain cells including glia and neurons remains t...

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Material Type: 博士論文
Title: Immunoreactivities for hepcidin, ferroportin, and hephaestin in astrocytes and choroid plexus epithelium of human brains
Author/Editor: 簗瀬, 賢
Author Heading: 簗瀬, 賢
Publication Date: 2021-03-24
Publication Date (W3CDTF): 2021-03-24
Alternative Title: ヒト脳アストロサイトと脈絡叢上皮におけるヘプシジン、フェロ-ポルチン、ヘファエスチンの免疫反応性
Degree grantor/type: 香川大学
Date Granted: 2021-03-24
Date Granted (W3CDTF): 2021-03-24
Dissertation Number: 甲第774号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第774号
Text Language Code: eng
Alias of Author: Yanase, Ken
Subject Heading: astrocyte
choroid plexus
ferroportin
hepcidin
hephaestin
Target Audience: 一般
Note (General): Iron plays essential roles in the central nervous system. However, how the iron level is regulated in brain cells including glia and neurons remains to be fully clarified. In this study, the localizations of hepcidin, ferroportin, and hephaestin, which are known to be involved in iron efflux, were immunohistochemically examined in autopsied human brains. Immunoreactivities for hepcidin and ferroportin were observed in granular structures within the cytoplasm of reactive astrocytes and epithelial cells of the choroid plexus. Granular structures showing immunoreactivities for hepcidin and ferroportin were also stained with antibodies for early endosome antigen 1 (EEA1). In addition, immunoreactivity for hephaestin was observed in the cytoplasm of epithelial cells of the choroid plexus as well as reactive astrocytes. Immunoreactivity for hephaestin in the cytoplasm of reactive astrocytes was occasionally colocalized with immunoreactivity for EEA1, while that of hephaestin was frequently observed in the cytoplasm showing no immunoreactivity for EEA1. These findings suggest that immunoreactivities for hepcidin and ferroportin are localized in close proximity to granular structures showing immunoreactivity for EEA1 in the cytoplasm of human brain astrocytes. They also suggest that immunoreactivity of hephaestin is localized in the cytoplasm of the choroid plexus epithelium as well as reactive astrocytes of human brains.
DOI: info:doi/10.1111/neup.12611
https://doi.org/info:doi/10.1111/neup.12611
Persistent ID (NDL): info:ndljp/pid/11671732
https://dl.ndl.go.jp/pid/11671732
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2021-05-16T23:51:55+09:00
Date Created (W3CDTF): 2021-04-22
Format (IMT): PDF
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): https://kagawa-u.repo.nii.ac.jp/records/7340
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp