Hyperthermic therapy using warm sterile water enhances cytocidal effects on bladder cancer cells

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DOI[info:doi/10.1080/21681805.2019.1708967]to the data of the same series

Hyperthermic therapy using warm sterile water enhances cytocidal effects on bladder cancer cells

Persistent ID (NDL): info:ndljp/pid/11671734

Material type: 博士論文

Author: 松岡, 祐貴

Publisher: -

Publication date: 2021-03-24

Material Format: Digital

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Name of awarding university/degree: 香川大学,博士（医学）

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Note (General)：: Objectives: To investigate whether warm sterile water enhances the cytocidal effect of hypotonic shock on bladder cancer cells that show resistance to...

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Material Type: 博士論文
Title: Hyperthermic therapy using warm sterile water enhances cytocidal effects on bladder cancer cells
Author/Editor: 松岡, 祐貴
Author Heading: 松岡, 祐貴
Publication Date: 2021-03-24
Publication Date (W3CDTF): 2021-03-24
Alternative Title: 熱刺激は蒸留水が示す膀胱癌細胞に対する殺細胞効果を増強する
Degree grantor/type: 香川大学
Date Granted: 2021-03-24
Date Granted (W3CDTF): 2021-03-24
Dissertation Number: 甲第776号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第776号
Text Language Code: eng
Alias of Author: Matsuoka, Yuki
Subject Heading: S: Bladder cancer
hypotonic shock
cytocidal
hyperthermic therapy
Target Audience: 一般
Note (General): Objectives: To investigate whether warm sterile water enhances the cytocidal effect of hypotonic shock on bladder cancer cells that show resistance to sterile water.
Methods: Four bladder cancer cell lines of varying grades (T24, RT4, J82, and RT112) were exposed to sterile water, and morphological changes were closely observed under microscopy. Changes in cell membrane integrity and cell viability after water exposure were measured to determine the effects of water-induced hypotonic shock. Additionally, the effects of warm sterile water were analyzed.
Results: T24, RT4, and J82 cells started swelling immediately upon exposure to water, followed by rupture within five minutes. RT112 cells demonstrated limited hypotonic swelling with significantly less cell rupture after 10 min. The percentages of viable cells at 10 min were 1.6 ± 0.8%, 3.5 ± 3.5%, 5.0 ± 3.2%, and 22.0 ± 10.3% for T24, RT4, J82, and RT112, respectively. The percentage of viable cells with 48 °C sterile water at one minute was 0% for RT112 cells.
Conclusions: These findings support the efficacy of sterile water against bladder cancer cells and reveal that warm sterile water enhances the cytocidal effects of hypotonic shock, potentially avoiding the need for radical surgery.
DOI: info:doi/10.1080/21681805.2019.1708967
https://doi.org/info:doi/10.1080/21681805.2019.1708967
Persistent ID (NDL): info:ndljp/pid/11671734
https://dl.ndl.go.jp/pid/11671734
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2021-05-16T23:51:55+09:00
Date Created (W3CDTF): 2021-04-22
Format (IMT): PDF
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): https://kagawa-u.repo.nii.ac.jp/records/7342
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp