Texture indices of 4′-[methyl-11C]-thiothymidine uptake predict p16 status in patients with newly diagnosed oropharyngeal squamous cell carcinoma : comparison with 18F-FDG uptake

• Material Type: 博士論文
• Title: Texture indices of 4′-[methyl-11C]-thiothymidine uptake predict p16 status in patients with newly diagnosed oropharyngeal squamous cell carcinoma : comparison with 18F-FDG uptake
• Author/Editor: 西下, あゆ美
• Author Heading: 西下, あゆ美
• Publication Date: 2021-03-24
• Publication Date (W3CDTF): 2021-03-24
• Alternative Title: 11C-4DST PETでの集積のテクスチャー解析は新規に診断された中咽頭扁平上皮癌患者のp16発現の有無を予測するか : 18F-FDG PET検査との比較
• Degree grantor/type: 香川大学
• Date Granted: 2021-03-24
• Date Granted (W3CDTF): 2021-03-24
• Dissertation Number: 甲第764号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第764号
• Text Language Code: eng
• Alias of Author: Ihara-Nishishita, Ayumi
• Subject Heading: 11C-4DST; 18F-FDG; PET; Oropharyngeal squamous cell carcinoma; Texture
• Target Audience: 一般
• Note (General): Background: In oropharyngeal squamous cell carcinoma (OPSCC), human papillomavirus (HPV)/p16 status is important as a prognostic biomarker.; Purpose: We evaluated the relationship between 4′-[methyl-11C]-thiothymidine (11C-4DST) and 18F-FDG PET texture indices and p16 status in patients with newly diagnosed OPSCC.; Methods: We retrospectively reviewed the collected data of 256 consecutive, previously untreated patients with primary head and neck tumors enrolled between November 2011 and October 2019. Complete data on both 11C-4DST and 18F-FDG PET/CT studies before therapy, patients with OPSCC, and p16 status were available for 34 patients. Six of them were excluded because they did not exhibit sufficient 11C-4DST and/or 18F-FDG tumor uptake to perform textural analysis. Finally, 28 patients with newly diagnosed OPSCC were investigated. The maximum standardized uptake value (SUVmax) and 6 texture indices (homogeneity, entropy, short-run emphasis, long-run emphasis, low gray-level zone emphasis, and high gray-level zone emphasis) were derived from PET images. The presence of p16 expression in tumor specimens was examined by immunohistochemistry and compared with the PET parameters.; Results: Using 11C-4DST, the expression of p16 was associated with a higher homogeneity (P = 0.012), lower short-run emphasis (P = 0.005), higher long-run emphasis (P = 0.009), and lower high-gray-level-zone emphasis (P = 0.042) values. There was no significant difference between 18F-FDG PET parameters and p16 status.; Conclusion: Texture indices of the primary tumor on 11C-4DST PET, but not 18F-FDG PET, may be of value in predicting the condition’s p16 status in patients with newly diagnosed OPSCC.
• DOI: info:doi/10.1186/s41824-020-00090-y; https://doi.org/info:doi/10.1186/s41824-020-00090-y
• Persistent ID (NDL): info:ndljp/pid/11671737; https://dl.ndl.go.jp/pid/11671737
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2021-05-16T23:51:55+09:00
• Date Created (W3CDTF): 2021-04-21
• Format (IMT): PDF
• Access Restrictions: 国立国会図書館内限定公開
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• Availability of remote photoduplication service: 可
• Periodical Title (URI): https://kagawa-u.repo.nii.ac.jp/records/7330
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp