Inflammatory Skin-Derived Cytokines Accelerate Osteoporosis in Mice with Persistent Skin Inflammation

• Material Type: 博士論文
• Title: Inflammatory Skin-Derived Cytokines Accelerate Osteoporosis in Mice with Persistent Skin Inflammation
• Author/Editor: Mizutani, Kento
• Author Heading: Mizutani, Kento
• Publication, Distribution, etc.: 三重大学
• Publication Date: 2020-09-16
• Publication Date (W3CDTF): 2020-09-16
• Degree grantor/type: 三重大学
• Date Granted: 2020-09-16
• Date Granted (W3CDTF): 2020-09-16
• Dissertation Number: 甲医学第2029号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲医学第2029号
• Text Language Code: eng
• Alias of Author: ミズタニ, ケント; 水谷, 健人
• Subject Heading: inflammatory skin mouse model; psoriasis; osteoporosis; minodronate; anti-RANKL antibody
• Target Audience: 一般
• Note (General): application/pdf; Secondary osteoporosis can also be caused by chronic inflammatory skin disease as well as rheumatoid arthritis or inflammatory bowel disease. However, the exact role of osteoporosis in inflammatory skin conditions has not been elucidated. Using a mouse model of dermatitis, we investigated the pathophysiology of osteoporosis in inflammatory skin conditions and the therapeutic impact of osteoporosis medication on inflammatory skin disease. We employed model mice of spontaneous skin inflammation, specifically overexpressing human caspase-1 in the epidermis. Bone density and the expression of various mRNAs in the femur were examined by micro CT and RT-PCR. The effects of minodronate and anti-RANKL antibody on bone structure, histology, and femur blood flow were studied. The mouse model of skin inflammation showed a marked decrease in bone density compared to wild-type littermates with abnormalities in both bone resorption and formation. Minodronate improved bone density by decreasing osteoclasts, but anti-RANKL antibody did not improve. In the dermatitis model, the blood flow in the bone marrow was decreased, and minodronate restored this parameter. A model of persistent dermatitis exhibited marked osteoporosis, but the impact of chronic dermatitis on osteoporosis has not been thoroughly investigated. We should explore the pathogenesis of osteoporosis in skin inflammatory diseases.; 本文/Department of Dermatology, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan; 13p
• DOI: info:doi/10.3390/ijms21103620; https://doi.org/info:doi/10.3390/ijms21103620
• Persistent ID (NDL): info:ndljp/pid/11671778; https://dl.ndl.go.jp/pid/11671778
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2021-05-16T23:51:55+09:00
• Date Created (W3CDTF): 2021-01-05
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10076/00019575; https://mie-u.repo.nii.ac.jp/records/13957
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp