Intensity-Modulated Radiation Therapy Optimization for Acceptable and Remaining-One Unacceptable Dose-Volume and Mean-Dose Constraint Planning

• Material Type: 博士論文
• ISSN: 1748-670X
• Title: Intensity-Modulated Radiation Therapy Optimization for Acceptable and Remaining-One Unacceptable Dose-Volume and Mean-Dose Constraint Planning
• Volume: 2020
• Author/Editor: Nakada, Ryosei; Abou Al-Ola, Omar M.; Yoshinaga, Tetsuya
• Author Heading: Nakada, Ryosei; Abou Al-Ola, Omar M.; Yoshinaga, Tetsuya
• Publication, Distribution, etc.: Hindawi
• Publication Date: 2020-09-03
• Publication Date (W3CDTF): 2020-09-03
• Alternative Title: 達成可能及び残り一つを除いて達成可能な線量体積・平均線量制約に基づく計画のための強度変調放射線治療の最適化
• Periodical title: Computational and Mathematical Methods in Medicine
• Degree grantor/type: 徳島大学
• Date Granted: 2021-02-18
• Date Granted (W3CDTF): 2021-02-18
• Dissertation Number: 甲第3475号
• Degree Type: 博士（保健学）
• Conferring No. (Dissertation): 甲第3475号
• Text Language Code: eng
• Subject Heading: IMRT optimization; nonlinear dynamical system; Lyapunov theorem
• Target Audience: 一般
• Note (General): We give a novel approach for obtaining an intensity-modulated radiation therapy (IMRT) optimization solution based on the idea of continuous dynamical methods. The proposed method, which is an iterative algorithm derived from the discretization of a continuous-time dynamical system, can handle not only dose-volume but also mean-dose constraints directly in IMRT treatment planning. A theoretical proof for the convergence to an equilibrium corresponding to the desired IMRT planning is given by using the Lyapunov stability theorem. By introducing the concept of “acceptable,” which means the existence of a nonempty set of beam weights satisfying the given dose-volume and mean-dose constraints, and by using the proposed method for an acceptable IMRT planning, one can resolve the issue that the objective and evaluation are different in the conventional planning process. Moreover, in the case where the target planning is totally unacceptable and partly acceptable except for one group of dose constraints, we give a procedure that enables us to obtain a nearly optimal solution close to the desired solution for unacceptable planning. The performance of the proposed approach for an acceptable or unacceptable planning is confirmed through numerical experiments simulating a clinical setup.
• DOI: info:doi/10.1155/2020/3096067; https://doi.org/info:doi/10.1155/2020/3096067
• Persistent ID (NDL): info:ndljp/pid/11671985; https://dl.ndl.go.jp/pid/11671985
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2021-05-16T23:51:55+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/115639
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp