Effects of Lactobacillus salivarius WB21 combined with green tea catechins on dental caries, periodontitis, and oral malodor.

• Material Type: 博士論文
• Title: Effects of Lactobacillus salivarius WB21 combined with green tea catechins on dental caries, periodontitis, and oral malodor.
• Author/Editor: Higuchi, Takuya; Suzuki, Nao; Nakaya, Seigo; Omagari, Sami; Yoneda, Masahiro; Hanioka, Takashi; Hirofuji, Takao
• Author Heading: Higuchi, Takuya; Suzuki, Nao; Nakaya, Seigo; Omagari, Sami; Yoneda, Masahiro; Hanioka, Takashi; Hirofuji, Takao
• Publication Date: 2020-03-30
• Publication Date (W3CDTF): 2020-03-30
• Alternative Title: Effects of Lactobacillus salivarius WB21 combined with green tea catechins on dental caries, periodontitis, and oral malodor.
• Degree grantor/type: 福岡歯科大学
• Date Granted: 2020-03-30
• Date Granted (W3CDTF): 2020-03-30
• Dissertation Number: 乙第100号
• Degree Type: 博士（歯学）
• Conferring No. (Dissertation): 乙第100号
• Text Language Code: eng
• Subject Heading: う蝕; エピガロカテキンガラート; Lactobacillus salivarius; 口臭; 歯周病; Antibiosis; Catechin; Dental Caries; Fusobacterium nucleatum; Glucans; Halitosis; Microbial Sensitivity Tests; Periodontitis; Porphyromonas gingivalis; Prevotella intermedia; Probiotics; Streptococcus mutans; Tea; (-)-Epigallocatechin gallate; Oral malodor
• Target Audience: 一般
• Note (General): To evaluate the combined use of Lactobacillus salivarius WB21 and (-)-epigallocatechin gallate (EGCg) for oral health maintenance.; The effects of L. salivarius WB21 on growth of Streptococcus mutans, the insoluble glucan produced by S. mutans, and on growth of Porphyromonas gingivalis were evaluated in vitro. In addition, the susceptibility of five oral pathogenic bacteria and L. salivarius WB21 to EGCg, the inhibiting effect of EGCg on methyl mercaptan, and the effects of L. salivarius WB21 and EGCg in combination on growth of P. gingivalis were examined.; Lactobacillus salivarius WB21 showed concentration-dependent inhibition of the growth of S. mutans. Addition of L. salivarius WB21 inhibited production of the insoluble glucan by S. mutans (p < 0.001). A filtrate of L. salivarius WB21 culture solution inhibited growth of P. gingivalis (p < 0.001 vs. control), and this effect was enhanced when it was used in combination with EGCg (p < 0.001 vs. the addition of L. salivarius WB21). In addition, EGCg directly inhibited methyl mercaptan in a concentration-dependent manner (p < 0.001). Concerning bacterial susceptibility to EGCg, growth of P. gingivalis, Prevotella intermedia, and Fusobacterium nucleatum was inhibited at 2.5 mg/mL of EGCg, while that of L. salivarius WB21 was inhibited at 25 mg/mL EGCg.; Our results imply that L. salivarius WB21 may be useful for controlling dental caries, periodontitis, and oral malodor. In addition, the effects of L. salivarius WB21 on periodontitis and oral malodor may be synergistically enhanced by use in combination with EGCg.; ScienceDirect
• Persistent ID (NDL): info:ndljp/pid/11673172; https://dl.ndl.go.jp/pid/11673172
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2021-05-20T03:24:30+09:00
• Date Created (W3CDTF): 2020-03-25
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Original Material (URI): https://doi.org/10.1016/j.archoralbio.2018.11.027
• Periodical Title (URI): https://fdc.repo.nii.ac.jp/records/109
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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