Glyburide inhibits the bone resorption induced by traumatic occlusion in rats.

Persistent ID (NDL): info:ndljp/pid/11673173

Material type: 博士論文

Author: Arita, Yoichiほか

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Publication date: 2020-03-14

Material Format: Digital

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Name of awarding university/degree: 福岡歯科大学,博士（歯学）

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Note (General)：: To examine whether glyburide inhibits bone destruction caused by traumatic occlusion in a rat occlusal trauma model.Excessive mechanical stress, such ...

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Material Type: 博士論文
Title: Glyburide inhibits the bone resorption induced by traumatic occlusion in rats.
Author/Editor: Arita, Yoichi
Yoshinaga, Yasunori
Kaneko, Takashi
Kawahara, Yuri
Nakamura, Keiko
Ohgi, Kimiko
Arita, Seiichi
Ryu, Takanori
Takase, Minoru
Sakagami, Ryuji
Publication Date: 2020-03-14
Publication Date (W3CDTF): 2020-03-14
Alternative Title: Glyburide inhibits the bone resorption induced by traumatic occlusion in rats.
Degree grantor/type: 福岡歯科大学
Date Granted: 2020-03-14
Date Granted (W3CDTF): 2020-03-14
Dissertation Number: 甲第313号
Degree Type: 博士（歯学）
Conferring No. (Dissertation): 甲第313号
Text Language Code: eng
Subject Heading: Glyburide
NLRP3 inhibitor
NLRP3
Occlusal trauma
IL-1β
Note (General): To examine whether glyburide inhibits bone destruction caused by traumatic occlusion in a rat occlusal trauma model.
Excessive mechanical stress, such as traumatic occlusion, induces expression of IL-1β and may be involved in bone resorption. NLRP3 inflammasomes have been linked to IL-1β expression, but it is currently unclear whether glyburide, the inhibiter of NLRP3 inflammasome, suppresses occlusal trauma in rats.
Male SD rats aged 7weeks were used. In the trauma group, the occlusal surface of the maxillary first right molar was raised by attaching a metal wire to apply occlusal trauma to the mandibular first right molar. In the trauma+glyburide group, the NLRP3 inhibitor glyburide was administered orally every 24hours from 1day before induction of occlusal trauma. Rats were euthanized after 5 or 10days, and the maxillary first molars were harvested with the adjacent tissues for histopathological investigation. Immunohistochemical expression of IL-1β, NLRP3, and RANKL was also assessed.
On day 5, bone resorption was significantly greater in the trauma group compared with the control group or the trauma+glyburide group, and there were significantly higher numbers of osteoclasts and cells positive for IL-1β, NLRP3, and RANKL in the trauma group.
In this study, glyburide inhibits bone resorption by traumatic occlusion in rats. It suggests that the NLRP3/IL-1β pathway might be associated with bone resorption induced by traumatic occlusion.
2019年度
元資料の権利情報 : CC BY-NC-ND
Persistent ID (NDL): info:ndljp/pid/11673173
https://dl.ndl.go.jp/pid/11673173
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2021-05-20T03:24:30+09:00
Date Created (W3CDTF): 2020-03-25
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Original Material (URI): https://doi.org/10.1111/jre.12731
Periodical Title (URI): http://id.nii.ac.jp/1167/00000090/
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