高フルクトース食は腸管上皮のバリア機能を障害し、DSS腸炎を悪化させる

• Material Type: 博士論文
• Title: 高フルクトース食は腸管上皮のバリア機能を障害し、DSS腸炎を悪化させる
• Volume: 43
• Author/Editor: 川畑, 活人
• Author Heading: 川畑, 活人
• Publication, Distribution, etc.: Spandidos Publications
• Publication Date: 2019; 43
• Publication Date (W3CDTF): 2019
• Alternative Title: A high-fructose diet induces epithelial barrier dysfunction and exacerbates the severity of dextran sulfate sodium-induced colitis
• Periodical title: International Journal of Molecular Medicine
• Degree grantor/type: 鹿児島大学
• Date Granted: 2020-02-17
• Date Granted (W3CDTF): 2020-02-17
• Dissertation Number: 甲総研第537号
• Degree Type: 博士(医学); Doctor of Philosophy in Medical Science
• Conferring No. (Dissertation): 甲総研第537号
• Text Language Code: eng
• Subject Heading: inflammatory bowel disease; fructose, paracellular permeability; tight junction; microbiota
• NDC: 490
• Target Audience: 一般
• Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; Excessive fructose intake is a risk factor for gut symptoms in patients with inflammatory bowel disease, however, its effect on the intestinal tract has not been evaluated previously. The present study investigated the impact of a high‑fructose diet (HFD) on intestinal barrier function in mice with experimental colitis. C57/BL6 mice were provided with either a HFD or control diet and either plain drinking water or water containing 1% dextran sulfate sodium (DSS) for 2 weeks. The disease activity index (DAI), pathological scores and expression of inflammatory cytokines were compared among the groups, and the proportions of fecal bacteria in the colon were analyzed. The body weight and colon length were significantly decreased, and the DAI and pathological scores were significantly increased in the DSS/HFD‑treated mice compared with the non‑D SS‑treated and control diet mice. Regarding the expression of inflammatory cytokines, the levels of interleukin (IL)‑6, IL‑1β and tumor necrosis factor‑α were significantly increased, and the expression of the tight junction protein occludin was significantly decreased in the DSS/HFD‑ treated mice. The total bacterial count was increased in the HFD mice. Taken together, these results indicate that an HFD resulted in the deterioration of intestinal barrier function and increased susceptibility to DSS‑induced colitis.Katsuto Kawabata, Shuji Kanmura, Yuko Morinaga, Akihito Tanaka, Tomoaki Makino, Toshihiro Fujita, Shiho Arima, Fumisato Sasaki, Yuichirou Nasu, Shiroh Tanoue, Shinichi Hashimoto, Akio IdoA high‑fructose diet induces epithelial barrier dysfunction and exacerbates the severity of dextran sulfate sodium‑induced colitisInternational Journal of Molecular Medicine, 43, 1487-1496, 2019DOI:https://doi.org/10.3892/ijmm.2018.4040
• DOI: info:doi/10.3892/ijmm.2018.4040; https://doi.org/info:doi/10.3892/ijmm.2018.4040
• Persistent ID (NDL): info:ndljp/pid/11673228; https://dl.ndl.go.jp/pid/11673228
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2021-05-20T03:24:30+09:00
• Date Created (W3CDTF): 2020-03-16
• Format (IMT): PDF; application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10232/00030893
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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