Tenascin C in the tumor-nerve microenvironment enhances perineural invasion and correlates with locoregional recurrence in pancreatic ductal adenocarcinoma

• Material Type: 博士論文
• ISSN: 0885-3177
• Title: Tenascin C in the tumor-nerve microenvironment enhances perineural invasion and correlates with locoregional recurrence in pancreatic ductal adenocarcinoma
• Volume: 49 3
• Author/Editor: 古橋, 暁
• Author Heading: 古橋, 暁
• Publication, Distribution, etc.: Wolters Kluwer Health
• Publication Date: 2020-03
• Publication Date (W3CDTF): 2020-03
• Alternative Title: 腫瘍神経微小環境に発現するテネイシンCが、浸潤性膵管がんにおいて神経周囲浸潤を促進し、局所領域再発と相関する
• Periodical title: Pancreas
• Degree grantor/type: 浜松医科大学
• Date Granted: 2020-03-16
• Date Granted (W3CDTF): 2020-03-16
• Dissertation Number: 甲第839号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第839号
• Text Language Code: eng
• Subject Heading: pancreatic ductal adenocarcinoma; perineural invasion; tenascin C; dorsal root ganglion; tumor-nerve microenvironment; neurotropism
• Target Audience: 一般
• Note (General): doctoral; 医学系研究科; Objectives: Perineural invasion (PNI) is common in pancreatic ductal adenocarcinoma (PDAC) and worsens the postoperative prognosis. Tenascin C (TNC), an extracellular matrix glycoprotein, modulates tumor progression. We evaluated the functional roles of TNC, especially in PNI of PDAC.Methods: We examined immunohistochemical TNC expression in 78 resected PDAC specimens. The relationships between TNC expression and clinicopathological features were retrospectively analyzed. Interactions between cancer cells and TNC-supplemented nerves were investigated using an in vitro co-culture model with PDAC cell line and mouse dorsal root ganglion (DRG).Results: Tenascin C expression was predominant in perineural sites at invasive tumor front. High perineural TNC expression in 30 patients (38%) was associated with PNI, pathological T stage ? 3, and postoperative locoregional recurrence. High TNC expression was independently associated with postoperative, poor recurrence-free survival by multivariate analysis. In the in vitro co-culture model, a TNC-rich matrix enhanced both PDAC cell colony extensions toward nerves and DRG axonal outgrowth toward cancer cell colonies, whereas TNC did not affect axonal outgrowth or cancer cell proliferation in separately cultured DRG and PDAC cells.Conclusions: Strong perineural TNC expression indicated poor prognosis with locoregional recurrence. The neurotropism of TNC-induced PDAC suggests TNC is a potential PDAC therapeutic target.
• DOI: info:doi/10.1097/MPA.0000000000001506; https://doi.org/info:doi/10.1097/MPA.0000000000001506
• Persistent ID (NDL): info:ndljp/pid/11675870; https://dl.ndl.go.jp/pid/11675870
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2021-05-30T17:29:36+09:00
• Date Created (W3CDTF): 2021-02-17
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10271/00003786; https://hama-med.repo.nii.ac.jp/records/3654
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2023-12-06 再収集