Coexistence of cerebral hypometabolism and neuroinflammation in the thalamo-limbic-brainstem region in young women with functional somatic syndrome

• Material Type: 博士論文
• ISSN: 2191-219X
• Title: Coexistence of cerebral hypometabolism and neuroinflammation in the thalamo-limbic-brainstem region in young women with functional somatic syndrome
• Volume: 10
• Author/Editor: 松平, 敬史
• Author Heading: 松平, 敬史
• Publication, Distribution, etc.: Springer Nature
• Publication Date: 2020-03-20
• Publication Date (W3CDTF): 2020-03-20
• Alternative Title: 機能性身体症候群若年女性における視床-辺縁系-脳幹部の脳内糖代謝低下と神経炎症の共在
• Periodical title: EJNMMI Research
• Degree grantor/type: 浜松医科大学
• Date Granted: 2020-06-19
• Date Granted (W3CDTF): 2020-06-19
• Dissertation Number: 甲第842号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第842号
• Text Language Code: eng
• Subject Heading: [11C]DPA713; [18F]FDG; Functional somatic syndrome; Glucose metabolism; Neuroinflammation; Positron emission tomography
• Target Audience: 一般
• Note (General): doctoral; 医学系研究科; Background: Functional somatic syndrome (FSS) is a disorder characterized by clusters of medically unexplained symptoms. Some women suffer from persistent FSS after human papillomavirus (HPV) vaccination. However, a causal relationship has not been established, and the pathophysiology of FSS remains elusive. Here, we aimed to identify the brain regions showing altered cerebral metabolism and neuroinflammation in patients with FSS and to correlate the measures of positron emission tomography (PET) with clinical data. Twelve women diagnosed with FSS following HPV vaccination (FSS group) underwent both [18F]FDG-PET to measure glucose metabolism and [11C]DPA713-PET to measure neuroinflammation. [18F]FDG standardized uptake value ratio (SUVR) and [11C]DPA713 binding potential (BPND) values were compared voxel-wise between the FSS and control groups (n=12 for [18F]FDG, n=16 for [11C]DPA713). A region-of-interest (ROI)-based analysis was performed to correlate PET parameters with clinical scores. Statistical significance was set at p < 0.05 corrected for multiple comparisons.Results: Statistical parametric mapping revealed a concomitant significant decrease of [18F]FDG SUVR and increase of [11C]DPA713 BPND in the regions covering the thalamus, mesial temporal area, and brainstem in the FSS group. Correlation analysis revealed that intelligence and memory scores were significantly positively correlated with [18F]FDG SUVR and negatively so with [11C]DPA713 BPND in these regions. A direct comparison between [18F]FDG SUVR and [11C]DPA713 BPND revealed a significant positive correlation in the right hippocampus and amygdala.Conclusions: Cerebral hypometabolism with neuroinflammation occurring in the thalamo-limbic-brainstem region may reflect the pathophysiology of FSS.
• DOI: info:doi/10.1186/s13550-020-00617-1; https://doi.org/info:doi/10.1186/s13550-020-00617-1
• Persistent ID (NDL): info:ndljp/pid/11675871; https://dl.ndl.go.jp/pid/11675871
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2021-05-30T17:29:36+09:00
• Date Created (W3CDTF): 2021-04-01
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10271/00003809; https://hama-med.repo.nii.ac.jp/records/3680
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2023-12-06 再収集