Effects of L-/N-Type Calcium Channel Blockers on Angiotensin II–Renin Feedback in Hypertensive Patients

• Material Type: 博士論文
• ISSN: 2090-0384
• Title: Effects of L-/N-Type Calcium Channel Blockers on Angiotensin II–Renin Feedback in Hypertensive Patients
• Volume: 2020
• Author/Editor: Kawabata, Yutaka; Soeki, Takeshi; Ito, Hiroyuki; Matsuura, Tomomi; Kusunose, Kenya; Ise, Takayuki; Yamaguchi, Koji; Tobiume, Takeshi; Yagi, Shusuke; Fukuda, Daiju; Yamada, Hirotsugu; Wakatsuki, Tetsuzo; Kitani, Mitsuhiro; Kawano, Kazuhiro; Taketani, Yoshio; Sata, Masataka
• Author Heading: Kawabata, Yutaka; Soeki, Takeshi; Ito, Hiroyuki; Matsuura, Tomomi; Kusunose, Kenya; Ise, Takayuki; Yamaguchi, Koji; Tobiume, Takeshi; Yagi, Shusuke; Fukuda, Daiju; Yamada, Hirotsugu; Wakatsuki, Tetsuzo; Kitani, Mitsuhiro; Kawano, Kazuhiro; Taketani, Yoshio; Sata, Masataka
• Publication, Distribution, etc.: Hindawi
• Publication Date: 2020-12-22
• Publication Date (W3CDTF): 2020-12-22
• Alternative Title: 高血圧患者におけるアンジオテンシン II-レニンフィードバック機構に対するL/N型カルシウムチャネル拮抗薬の影響
• Periodical title: International Journal of Hypertension
• Degree grantor/type: 徳島大学
• Date Granted: 2021-02-25
• Date Granted (W3CDTF): 2021-02-25
• Dissertation Number: 甲第3478号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第3478号
• Text Language Code: eng
• Subject Heading: L-/N-type calcium channel blocker; renoprotective effect; suppressing renin-angiotensin system; the ratio of Angiotensin-(1–7)/Angiotensin II
• Target Audience: 一般
• Note (General): Objectives. Cilnidipine, an L-/N-type calcium channel blocker (CCB), has unique organ-protective properties due to suppression of hyperactivity in the sympathetic nervous system and renin-angiotensin system (RAS). In this study, we hypothesized that cilnidipine might exert a renoprotective effect by suppressing the RAS.Methods. A total of 25 hypertensive patients receiving a RAS inhibitor were randomly assigned to a cilnidipine (n = 12) or amlodipine (n = 13) group. The effects of cilnidipine on proteinuria and angiotensin II–renin feedback were assessed.Results. After 6 months of treatment, both systolic and diastolic blood pressures were significantly reduced to a similar extent in both groups. The urine albumin-to-creatinine ratio was significantly lower in the cilnidipine group (p < 0.05) than in the amlodipine group. Amlodipine increased plasma angiotensin I and angiotensin II levels (p < 0.05), whereas cilnidipine did not. Interestingly, the cilnidipine group had a higher ratio of angiotensin-(1–7) (Ang-(1–7)) to angiotensin II in plasma than the amlodipine group (p < 0.05).Conclusions. The L-/N-type CCB cilnidipine, but not amlodipine, decreased urinary albumin excretion in hypertensive patients. Cilnidipine also increased the ratio of Ang-(1–7) to angiotensin II in plasma, which might be one factor underlying its beneficial effects.
• DOI: info:doi/10.1155/2020/6653851; https://doi.org/info:doi/10.1155/2020/6653851
• Persistent ID (NDL): info:ndljp/pid/11679083; https://dl.ndl.go.jp/pid/11679083
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• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2021-06-07T02:06:26+09:00
• Format (IMT): application/pdf
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• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/115937
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