Development of a novel gripping test for the evaluation of the finger fine motor ability in MPTP-treated monkeys

• Material Type: 博士論文
• ISSN: 0219-6352
• Title: Development of a novel gripping test for the evaluation of the finger fine motor ability in MPTP-treated monkeys
• Volume: 19 2
• Author/Editor: 小林, 奨
• Author Heading: 小林, 奨
• Publication, Distribution, etc.: IMR Press
• Publication Date: 2020-06-30
• Publication Date (W3CDTF): 2020-06-30
• Alternative Title: MPTP処置をしたサルにおける指微細運動能力評価を目的としたグリッピングテストの新規開発
• Periodical title: Journal of Integrative Neuroscience
• Degree grantor/type: 浜松医科大学
• Date Granted: 2020-09-18
• Date Granted (W3CDTF): 2020-09-18
• Dissertation Number: 甲第843号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第843号
• Text Language Code: eng
• Subject Heading: Parkinson's disease; levodopa; deep brain stimulation; behavioral test; finger fine motor skill; gross motor skill
• Target Audience: 一般
• Note (General): doctoral; 医学系研究科; Assessing the finger fine motor ability is extremely important. However, conventional behavioral tests in monkeys are complicated and costly. We attempted to develop a new task to assess the precise finger grip in Parkinson's disease monkeys based on the principles of objectification, multipurpose, and simplification. This study involved seven adult male cynomolgus monkeys. A gripping test based on the previous food reaching test was developed. Parallel experiments of food reaching test and gripping test affected by the treatments of levodopa and deep brain stimulation of the subthalamic nucleus were performed to verify the utility of the gripping test. We found that gross motor ability (measured by food reaching test) could be significantly improved by both the subthalamic nucleus and levodopa administration, which reproduced the results of our previous study. The finger fine motor ability (measured by the gripping test) could be significantly improved by levodopa administration, but not by the subthalamic nucleus. Our results verified the utility and reliability of the gripping test, which is a simple, convenient, and objective task for evaluating the finger fine motor skill in Parkinson's disease monkeys. Mechanisms of the efficacy of deep brain stimulation on fine motor ability require further investigation.
• DOI: info:doi/10.31083/j.jin.2020.02.158; https://doi.org/info:doi/10.31083/j.jin.2020.02.158
• Persistent ID (NDL): info:ndljp/pid/11679130; https://dl.ndl.go.jp/pid/11679130
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2021-06-07T02:06:26+09:00
• Date Created (W3CDTF): 2021-04-30
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10271/00003851; https://hama-med.repo.nii.ac.jp/records/3722
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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