淡明腎細胞癌において、miRNA-1274aを抑制することによりBMPR1Bの発現が回復し、癌細胞のアポトーシスが誘導される

• Material Type: 博士論文
• Title: 淡明腎細胞癌において、miRNA-1274aを抑制することによりBMPR1Bの発現が回復し、癌細胞のアポトーシスが誘導される
• Author/Editor: 米澤, 智一
• Author Heading: 米澤, 智一
• Publication, Distribution, etc.: Spandidos Publications
• Publication Date: 2021-05-17
• Publication Date (W3CDTF): 2021-05-17
• Alternative Title: Downregulation of microRNA-1274a induces cell apoptosis through regulation of BMPR1B in clear cell renal cell carcinoma
• Degree grantor/type: 鹿児島大学
• Date Granted: 2021-05-17
• Date Granted (W3CDTF): 2021-05-17
• Dissertation Number: 甲総研第605号
• Degree Type: 博士(医学); Doctor of Philosophy in Medical Science
• Conferring No. (Dissertation): 甲総研第605号
• Text Language Code: eng
• Subject Heading: microRNA; miR-1274a; renal cell carcinoma; apoptosis; upregulated miRNA
• NDC: 490
• Target Audience: 一般
• Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; Our previous studies of the microRNA (miRNA) expression signature in clear cell renal cell carcinoma (ccRCC) indicated that miRNA-1274a (miR-1274a) was significantly upregulated in clinical specimens, suggesting that miR-1274a may act as an oncogenic miRNA in ccRCC. The aim of this study was to investigate the functional roles of miR-1274a and identify downstream tumor-suppressive targets regulated by miR‑1274a in ccRCC cells. Functional studies of miR-1274a were carried out by anti-miRNA to investigate cell proliferation and apoptosis using the A498, ACHN and Caki1 ccRCC cell lines. Suppression of miR-1274a significantly inhibited cancer cell proliferation and induced apoptosis in the ccRCC cells. Gene expression data combined with in silico analysis and luciferase reporter assays demonstrated that bone morphogenetic protein receptor type 1B (BMPR1B) was directly regulated by miR-1274a. Moreover, TCGA database as well as immunohistochemistry demonstrated low expression of BMPR1B in ccRCC clinical specimens compared to that in normal kidney tissues. We conclude that loss of oncogenic miR-1274a reduced cancer cell proliferation and induced apoptosis in ccRCC through targeting BMPR1B. Our data revealing molecular pathways and a target gene regulated by oncogenic miR-1274a provide new insight into the potential mechanisms of ccRCC oncogenesis.Hirofumi Yoshino, Tomokazu Yonezawa, Masaya Yonemori, Kazutaka Miyamoto, Takashi Sakaguchi, Satoru Sugita, Youichi Osako, Shuichi Tatarano, Masayuki Nakagawa, Hideki EnokidaDownregulation of microRNA-1274a induces cell apoptosis through regulation of BMPR1B in clear cell renal cell carcinomaOncology Reports 2018 39(1) p.173-181https://doi.org/10.3892/or.2017.6098
• Persistent ID (NDL): info:ndljp/pid/11679439; https://dl.ndl.go.jp/pid/11679439
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2021-06-07T02:06:26+09:00
• Date Created (W3CDTF): 2021-05-26
• Format (IMT): PDF; application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10232/00031758
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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