Vibrio parahaemolyticus induces inflammation-associated fluid accumulation via activation of the cystic fibrosis transmembrane conductance regulator

• Material Type: 博士論文
• ISSN: 1349-6867
• Title: Vibrio parahaemolyticus induces inflammation-associated fluid accumulation via activation of the cystic fibrosis transmembrane conductance regulator
• Volume: 68 1-2
• Author/Editor: Iba, Hitomi; Shimohata, Takaaki; Kido, Junko; Hatayama, Sho; Uebanso, Takashi; Mawatari, Kazuaki; Takahashi, Akira
• Author Heading: Iba, Hitomi; Shimohata, Takaaki; Kido, Junko; Hatayama, Sho; Uebanso, Takashi; Mawatari, Kazuaki; Takahashi, Akira
• Publication, Distribution, etc.: Tokushima University Faculty of Medicine
• Publication Date: 2021-02
• Publication Date (W3CDTF): 2021-02
• Alternative Title: 腸炎ビブリオは炎症を誘導し、Cystic Fibrosis Transmembrane Conductance Regulatorを介して下痢を誘導する; CFTR associated diarrhea in VP-infection
• Periodical title: The Journal of Medical Investigation
• Degree grantor/type: 徳島大学
• Date Granted: 2021-01-28
• Date Granted (W3CDTF): 2021-01-28
• Dissertation Number: 甲第3471号
• Degree Type: 博士（栄養学）
• Conferring No. (Dissertation): 甲第3471号
• Text Language Code: eng
• Subject Heading: Vibrio parahaemolyticus; CFTR; inflammation; diarrhea; COX-2
• Target Audience: 一般
• Note (General): Vibrio parahaemolyticus is a foodborne bacterium that causes acute gastroenteritis through the consumption of contaminated, raw, or undercooked seafood. Cystic fibrosis transmembrane conductance regulator (CFTR) is a well-characterized chloride channel that regulates several other ion channels and transporters to maintain water homeostasis in the gut lumen. Also, CFTR is a main target of bacterial infection-associated diarrhea. Hence, the aim of this study was to clarify the contribution of CFTR in V. parahaemolyticus-induced diarrhea in a mouse model of intestinal loop fluid accumulation, with CFTR inhibitors and a CFTR knockout model. The results indicated that CFTR plays a critical role in fluid accumulation in response to V. parahaemolyticus infection. We also investigated the inflammatory association in CFTR-mediated V. parahaemolyticus-induced fluid secretion with cyclooxygenase inhibitors and found that fluid accumulation was decreased by inhibition of cyclooxygenase 2 produced by neutrophils. These findings suggest that V. parahaemolyticus-inducing infiltration and activation of neutrophils also participated in CFTR mediated fluid secretion. This study reveals an important relationship between V. parahaemolyticus-induced diarrhea and inflammation in a mouse model.
• DOI: info:doi/10.2152/jmi.68.59; https://doi.org/info:doi/10.2152/jmi.68.59
• Persistent ID (NDL): info:ndljp/pid/11680052; https://dl.ndl.go.jp/pid/11680052
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2021-06-07T02:06:26+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/115628
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp