Intracranial mast cells contribute to the control of social behavior in male mice

Persistent ID (NDL): info:ndljp/pid/11692593

Material type: 博士論文

Author: Tanioka, Daisukeほか

Publisher: Elsevier

Publication date: 2021-01-28

Material Format: Digital

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Name of awarding university/degree: 徳島大学,博士（医学）

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Note (General)：: Mast cells (MCs) exist intracranially and have been reported to affect higher brain functions in rodents. However, the role of MCs in the regulation o...

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Material Type: 博士論文
ISSN: 0166-4328
Title: Intracranial mast cells contribute to the control of social behavior in male mice
Volume: 403
Author/Editor: Tanioka, Daisuke
Chikahisa, Sachiko
Shimizu, Noriyuki
Shiuchi, Tetsuya
Sakai, Noriaki
Nishino, Seiji
Séi, Hiroyoshi
Author Heading: Tanioka, Daisuke
Chikahisa, Sachiko
Shimizu, Noriyuki
Shiuchi, Tetsuya
Sakai, Noriaki
Nishino, Seiji
Séi, Hiroyoshi
Publication, Distribution, etc.: Elsevier
Publication Date: 2021-01-28
Publication Date (W3CDTF): 2021-01-28
Alternative Title: 雄性マウス頭蓋内肥満細胞が担う社会性行動の調節
Periodical title: Behavioural Brain Research
Degree grantor/type: 徳島大学
Date Granted: 2021-03-23
Date Granted (W3CDTF): 2021-03-23
Dissertation Number: 甲第3500号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第3500号
Text Language Code: eng
Subject Heading: Mast cell
Social behavior
Intracranium
Serotonin
Compound 48/80
Target Audience: 一般
Note (General): Mast cells (MCs) exist intracranially and have been reported to affect higher brain functions in rodents. However, the role of MCs in the regulation of emotionality and social behavior is unclear. In the present study, using male mice, we examined the relationship between MCs and social behavior and investigated the underlying mechanisms. Wild-type male mice intraventricularly injected with a degranulator of MCs exhibited a marked increase in a three-chamber sociability test. In addition, removal of MCs in Mast cell-specific Toxin Receptor-mediated Conditional cell Knock out (Mas-TRECK) male mice showed reduced social preference levels in a three-chamber sociability test without other behavioral changes, such as anxiety-like and depression-like behavior. Mas-TRECK male mice also had reduced serotonin content and serotonin receptor expression and increased oxytocin receptor expression in the brain. These results suggested that MCs may contribute to the regulation of social behavior in male mice. This effect may be partially mediated by serotonin derived from MCs in the brain.
DOI: info:doi/10.1016/j.bbr.2021.113143
https://doi.org/info:doi/10.1016/j.bbr.2021.113143
Persistent ID (NDL): info:ndljp/pid/11692593
https://dl.ndl.go.jp/pid/11692593
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2021-07-05T22:24:43+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/116053
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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