Aging of the crystalline lens from the viewpoint of anti-glycation and anti-oxidation.

• Material Type: 記事
• Title: Aging of the crystalline lens from the viewpoint of anti-glycation and anti-oxidation.
• Author/Editor: Eri Kubo
• Publication, Distribution, etc.: 日本 : 糖化ストレス研究会
• Publication Date: 2020-12-31
• Publication Date (W3CDTF): 2020-12-31
• Alternative Title: 抗糖化、抗酸化からみた水晶体の老化
• Periodical title: Glycative stress research
• No. or year of volume/issue: 7(4)
• Volume: 7(4)
• ISSN (Periodical Title): 2188-3610
• ISSN-L (Periodical Title): 2188-3610
• Text Language Code: eng; jpn
• DOI: 10.24659/gsr.7.4_283; https://doi.org/10.24659/gsr.7.4_283
• Persistent ID (NDL): info:ndljp/pid/11703331; https://dl.ndl.go.jp/pid/11703331
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > 電子書籍・電子雑誌 > その他; https://dl.ndl.go.jp/collections/B00035
• Acquisition Basis: オンライン資料収集制度
• Date Accepted (W3CDTF): 2021-07-14T21:40:34+09:00
• Date Captured (W3CDTF): 2021-05-23
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): https://www.toukastress.jp/webj/
• Periodical Title (Persistent ID (NDL)): info:ndljp/pid/11703328; https://dl.ndl.go.jp/pid/11703328
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

• Collection (particular): 国立国会図書館デジタルコレクション > 電子書籍・電子雑誌 > その他; https://dl.ndl.go.jp/collections/B00035
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Holding library: 国立国会図書館
• Call No.: Z63-D541
• Related Material (URI): https://dl.ndl.go.jp/info:ndljp/pid/11703331
• Related Material (Persistent ID (NDL)): info:ndljp/pid/11703331; https://dl.ndl.go.jp/info:ndljp/pid/11703331
• Data Provider (Database): 国立国会図書館 : 国立国会図書館雑誌記事索引; https://ndlsearch.ndl.go.jp
• Bibliographic ID (NDL): 031484954; http://id.ndl.go.jp/bib/031484954
• Bibliographic Record Category (NDL): 632

• Summary, etc.: Ultraviolet rays, smoking, and drugs are considered to be risk factors for presbyopia and age-related cataracts. These cause oxidative stress and glycative stress, therebyinducing disulfide bond (S-S bond) formation, followed by aggregation / denaturation and hardening of the nucleus of the lens protein, resulting in the formation of presbyopia and cataracts. Therefore, antioxidant treatment and anti-glycation treatment can be expected to have a preventive / suppressive effect on cataracts and presbyopia. We have succeeded in delaying the progression of cataracts in the genetic cataract model, Shumiya Cataract Rat (SCR), by oral administration of an antioxidant lutein (LU) and anti-glycation water chestnut (Trapa bispinosa Roxb.) extract (TBE), where it was shown to increase the expression of the endogenous antioxidant protein peroxiredoxin 6 (Prdx6) and catalase in lens epithelial cells. Therefore, it can be effective in preventing cataracts to reduce not only the crystalline lens but also the whole body of oxidative and glycative stress and increase the endogenous antioxidant protein by ingesting antioxidants and anti-glycation supplements.
• DOI: 10.24659/gsr.7.4_283
• Access Restrictions: インターネット公開
• Data Provider (Database): 科学技術振興機構 : J-STAGE; http://www.jstage.jst.go.jp

• Summary, etc.: Ultraviolet rays, smoking, and drugs are considered to be risk factors for presbyopia and age-related cataracts. These cause oxidative stress and glycative stress, therebyinducing disulfide bond (S-S bond) formation, followed by aggregation / denaturation and hardening of the nucleus of the lens protein, resulting in the formation of presbyopia and cataracts. Therefore, antioxidant treatment and anti-glycation treatment can be expected to have a preventive / suppressive effect on cataracts and presbyopia. We have succeeded in delaying the progression of cataracts in the genetic cataract model, Shumiya Cataract Rat (SCR), by oral administration of an antioxidant lutein (LU) and anti-glycation water chestnut (Trapa bispinosa Roxb.) extract (TBE), where it was shown to increase the expression of the endogenous antioxidant protein peroxiredoxin 6 (Prdx6) and catalase in lens epithelial cells. Therefore, it can be effective in preventing cataracts to reduce not only the crystalline lens but also the whole body of oxidative and glycative stress and increase the endogenous antioxidant protein by ingesting antioxidants and anti-glycation supplements.
• DOI: 10.24659/gsr.7.4_283; https://doi.org/10.24659/gsr.7.4_283
• Related Material (URI): http://id.ndl.go.jp/bib/031484954; https://ndlsearch.ndl.go.jp/books/R000000004-I031484954; https://dl.ndl.go.jp/pid/11703331; http://id.ndl.go.jp/digimeta/11703331; https://search.jamas.or.jp/link/ui/2021267210
• Data Provider (Database): 国立情報学研究所 : CiNii Research; https://cir.nii.ac.jp/
• Original Data Provider (Database): Japan Link Center; https://japanlinkcenter.org/top; 雑誌記事索引データベース; https://ndlsearch.ndl.go.jp; CiNii Articles
• Bibliographic ID (NDL): 031484954; http://id.ndl.go.jp/bib/031484954; 11703331; http://id.ndl.go.jp/bib/11703331
• NAID: 130007964752

Table of Contents

本文

日本語翻訳版