Characteristics of bilirubin photochemical changes under green light-emitting diodes in humans compared with animal species

• Material Type: 博士論文
• Title: Characteristics of bilirubin photochemical changes under green light-emitting diodes in humans compared with animal species
• Author/Editor: 新居, 広一郎
• Author Heading: 新居, 広一郎
• Publication Date: 2021-06-29
• Publication Date (W3CDTF): 2021-06-29
• Alternative Title: 緑色発光ダイオード下でのビリルビン光化学反応の特徴 :ヒトと動物種間での比較検討
• Degree grantor/type: 香川大学
• Date Granted: 2021-06-29
• Date Granted (W3CDTF): 2021-06-29
• Dissertation Number: 甲第780号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第780号
• Text Language Code: eng
• Alias of Author: Nii, Kohichiroh
• Subject Heading: Biochemistry; Chemical biology; Biophysical chemistry; Experimental models of disease; Paediatric research; Lasers; LEDs and light sources
• Target Audience: 一般
• Note (General): Phototherapy using light-emitting diodes (LEDs) centered on the green spectrum, which has a high cyclobilirubin production rate, was as effective as that centered on the blue spectrum for neonatal hyperbilirubinemia. There are no reports of species differences in bilirubin photochemical changes in this spectrum, and the characteristics of bilirubin photochemical changes in humans must be elucidated to proceed with the development of new light sources that include these spectra. This report describes the characteristic photochemical kinetics of bilirubin under green-spectrum LEDs in human, rat, rabbit, dog, pig, sheep, bovine and chicken serum albumin and rhesus monkey serum. These albumin-bilirubin complex solutions were irradiated by green LEDs, and the time-course changes in bilirubin photoisomers were measured by high-performance liquid chromatography. The cyclobilirubin production rates in humans, pigs, and monkeys were significantly higher than those in other species. The rate constant of (EZ)-cyclobilirubin production from (EZ)-bilirubin ‘k’ was significantly higher in humans and monkeys than in other species. In conclusion, bilirubin photochemical kinetics under green spectrum LEDs in humans were characterized by a high cyclobilirubin production rate at a low substrate concentration. The bilirubin photochemical kinetics in monkeys were similar to those in humans.
• DOI: info:doi/10.1038/s41598-021-85632-5; https://doi.org/info:doi/10.1038/s41598-021-85632-5
• Persistent ID (NDL): info:ndljp/pid/11710746; https://dl.ndl.go.jp/pid/11710746
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2021-08-09T17:15:52+09:00
• Date Created (W3CDTF): 2021-07-13
• Format (IMT): PDF
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): https://kagawa-u.repo.nii.ac.jp/records/7450
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp