Significance of abnormal 53BP1 expression as a novel molecular pathologic parameter of follicular-shaped B-cell lymphoid lesions in human digestive tract

• Material Type: 博士論文
• ISSN: 2045-2322
• Title: Significance of abnormal 53BP1 expression as a novel molecular pathologic parameter of follicular-shaped B-cell lymphoid lesions in human digestive tract
• Volume: 11
• Author/Editor: Luong, Thi My Hanh
• Author Heading: Luong, Thi My Hanh
• Publication, Distribution, etc.: Springer Nature Limited
• Publication Date: 2021-02-04
• Publication Date (W3CDTF): 2021-02-04
• Alternative Title: ヒト消化管濾胞形成B細胞性リンパ球病変の新規分子病理学的指標として53BP1発現異常は有用である
• Periodical title: Scientific Reports
• Degree grantor/type: Nagasaki University (長崎大学)
• Date Granted: 2021-06-02
• Date Granted (W3CDTF): 2021-06-02
• Dissertation Number: 甲共医歯薬第13号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲共医歯薬第13号
• Text Language Code: eng
• Target Audience: 一般
• Note (General): The digestive tract is a common site of extranodal malignant lymphomas (MLs) and benign lymphoid lesions (BLs). TP53-binding protein 1 (53BP1) expression has been widely investigated in class switch recombination but rarely in human lymphoid tissues with respect to tumorigenesis. We previously reported that immunofluorescence (IF) analysis of 53BP1 nuclear foci (NF), reflecting DNA double strand breaks, is useful for estimating genomic instability in different tumor types. In this study, we evaluated the potential of IF-based analysis of 53BP1 expression in differentiating MLs from BLs. We examined 231 biopsied tissue samples of primary MLs and BLs in the digestive tract. The 53BP1 immunoreactivity pattern was determined by multicolor IF. Compared to BLs, MLs showed a high frequency of abnormal 53BP1 expression (p < 0.0001). Statistically, abnormal 53BP1 expression is an effective test for distinguishing follicular lymphomas from BLs (specificity 98.6%, sensitivity 86.8%) and for distinguishing small B-cell lymphomas from BLs (specificity 98.3%, sensitivity 77.6%). Furthermore, a high frequency of abnormal 53BP1 expression was associated with “high-risk” MALT lymphomas, which exhibited t(11;18)(q21;21) (p = 0.0145). Collectively, these results suggest that IF-based analysis of 53BP1 expression in biopsy samples is a promising technique for diagnosing MLs in the digestive system.; 長崎大学学位論文 学位記番号:共博（医歯薬）甲第13号 学位授与年月日:令和3年6月2日; Author: Luong Thi My Hanh, Katsuya Matsuda, Daisuke Niino, Hirokazu Kurohama, Masahiro Ito & Masahiro Nakashima; Citation: Scientific Reports, 11, art. no. 3074 ; 2021; identifier:Nagasaki University (長崎大学), 博士(医学) (2021-06-02); http://hdl.handle.net/10069/00040843
• DOI: info:doi/10.1038/s41598-021-82867-0; https://doi.org/info:doi/10.1038/s41598-021-82867-0
• Persistent ID (NDL): info:ndljp/pid/11710929; https://dl.ndl.go.jp/pid/11710929
• Collection: 障害者向け資料
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• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2021-08-09T17:15:52+09:00
• Date Created (W3CDTF): 2021-07-02
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
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• Related Material (URI): http://hdl.handle.net/10069/00040843
• Periodical Title (URI): http://hdl.handle.net/10069/00040853
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp