Alcohol drinking and brain morphometry in apparently healthy community-dwelling Japanese men.

• Material Type: 博士論文
• ISSN: 1873-6823
• Title: Alcohol drinking and brain morphometry in apparently healthy community-dwelling Japanese men.
• Volume: 90
• Author/Editor: SYAIFULLAH, Ali Haidar
• Author Heading: SYAIFULLAH, Ali Haidar
• Publication, Distribution, etc.: Elsevier B.V.
• Publication Date: 2021-02
• Publication Date (W3CDTF): 2021-02
• Periodical title: Alcohol (Fayetteville, N.Y.)
• Degree grantor/type: 滋賀医科大学
• Date Granted: 2021-03-09
• Date Granted (W3CDTF): 2021-03-09
• Dissertation Number: 甲第904号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第904号
• Text Language Code: eng
• Subject Heading: alcohol consumption; brain atrophy; japanese population; neuroimaging; voxel-based morphometry
• Target Audience: 一般
• Note (General): pdf; The clinical implications of alcohol consumption have been extensively examined; however, its effects on brain structures in apparently healthy community-dwellers remain unclear. Therefore, we investigated the relationship between alcohol consumption and brain gray matter volume (GMV) in community-dwelling Japanese men using voxel-based morphometry (VBM). We recruited cognitively intact Japanese men, aged 40-79 years, from a population-based cohort in Shiga, Japan. Brain magnetic resonance imaging was performed, on average, 2 years after demographic and medical information was obtained in 2010-2014. A multivariable linear regression analysis of 639 men was conducted to elucidate the relationship between the amount of alcohol consumed and GMV. VBM statistics were analyzed by threshold-free cluster enhancement with a family-wise error rate of <0.05. The results obtained demonstrated that the amount of alcohol consumed was associated with lower GMV. The VBM analysis showed lower GMV within the parahippocampal, entorhinal, cingulate, insular, temporal, and frontal cortices and cerebellum in very heavy drinkers (≥42 ethanol g/day) than in non-drinkers. Furthermore, alcohol consumption was associated with a higher white matter lesion volume. These results suggest subclinical structural changes similar to alcohol-related neurological diseases.; Thesis or Dissertation; 令和2年度; 10.1016/j.alcohol.2020.11.006; 博士論文要旨
• DOI: info:doi/10.1016/j.alcohol.2020.11.006; https://doi.org/info:doi/10.1016/j.alcohol.2020.11.006
• Persistent ID (NDL): info:ndljp/pid/11710936; https://dl.ndl.go.jp/pid/11710936
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2021-08-09T17:15:52+09:00
• Date Created (W3CDTF): 2021-07-14
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Related Material (URI): http://hdl.handle.net/10422/00013003
• Periodical Title (URI): http://hdl.handle.net/10422/00013043; https://shiga-med.repo.nii.ac.jp/records/3945
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2023-09-08 再収集