上気道流体シミュレーションを用いた小児閉塞性睡眠時無呼吸症の原因部位特定方法の確立

• Material Type: 博士論文
• Title: 上気道流体シミュレーションを用いた小児閉塞性睡眠時無呼吸症の原因部位特定方法の確立
• Author/Editor: 柳澤, 彩佳
• Author Heading: 柳澤, 彩佳
• Publication, Distribution, etc.: American Academy of Sleep Medicine
• Publication Date: 2020-03-25
• Publication Date (W3CDTF): 2020-03-25
• Alternative Title: Primary site identification in children with obstructive sleep apnea by computational fluid dynamics analysis of the upper airway
• Degree grantor/type: 鹿児島大学
• Date Granted: 2020-03-25
• Date Granted (W3CDTF): 2020-03-25
• Dissertation Number: 甲総研第545号
• Degree Type: 博士(歯学); Doctor of Philosophy in Dental Science
• Conferring No. (Dissertation): 甲総研第545号
• Text Language Code: eng
• Subject Heading: computed fluid dynamics; children; obstruction site; primary site; obstructive sleep apnea; airway velocity; airway pressure
• NDC: 490
• Target Audience: 一般
• Note (General): 博士論文全文, 博士論文要旨, 最終試験結果の要旨, 論文審査の要旨; Study Objectives: Obstructive sleep apnea (OSA) is a respiratory disorder caused by the obstruction of the upper airway during sleep. The identification of the primary site of OSA is essential to determine treatment strategy. This study aimed to establish computational fluid dynamics (CFD) analysis for determining the clinical severity of OSA and the primary site of OSA.Methods: Twenty children (mean age, 6 years) were divided into OSA and control groups according to their apnea hypopnea index. Three-dimensional airways were constructed from computed tomography data. The pharyngeal airway morphology and the pressure and velocity of the upper airway were evaluated using CFD analysis.Results: The maximum velocity and pressure of the upper airway in the OSA group were significantly correlated with the severity of OSA (rs = 0.741, P < 0.001; rs = 0.653, P = 0.002). A velocity higher than 12 m/s indicated the primary site of OSA. In addition, we found that the primary site of OSA is not necessarily the same as the collapsible conduit site.Conclusions: CFD analysis allows both the evaluation of the disease severity of OSA and the identification of the primary site of OSA in children. The primary site of OSA is not necessarily the same as the collapsible conduit site; therefore, CFD analysis can be used to identify the appropriate intervention for treating OSA.Ayaka Yanagisawa-Minami, Takeshi Sugiyama, Tomonori Iwasaki, Youichi YamasakiPrimary site identification in children with obstructive sleep apnea by computational fluid dynamics analysis of the upper airwayJournal of Clinical Sleep Medicine 16(3) 2020https://doi.org/10.5664/jcsm.8224This article has been accepted for publication in the Journal of Clinical Sleep Medicine published by the American Academy of Sleep Medicine
• Persistent ID (NDL): info:ndljp/pid/11710979; https://dl.ndl.go.jp/pid/11710979
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2021-08-09T17:15:52+09:00
• Date Created (W3CDTF): 2020-05-21
• Format (IMT): PDF; application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10232/00031069
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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