Suprabasin-null mice retain skin barrier function and show high contact hypersensitivity to nickel upon oral nickel loading

• Material Type: 博士論文
• ISSN: 2045-2322
• Title: Suprabasin-null mice retain skin barrier function and show high contact hypersensitivity to nickel upon oral nickel loading
• Volume: 10
• Author/Editor: 中澤, 慎介
• Author Heading: 中澤, 慎介
• Publication, Distribution, etc.: Springer Nature
• Publication Date: 2020
• Publication Date (W3CDTF): 2020
• Alternative Title: スプラバシンノックアウトマウスは皮膚バリア機能を保持し経口ニッケル負荷でニッケル接触過敏症が亢進する
• Periodical title: Scientific Reports
• Degree grantor/type: 浜松医科大学
• Date Granted: 2020-11-20
• Date Granted (W3CDTF): 2020-11-20
• Dissertation Number: 甲第848号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第848号
• Text Language Code: eng
• Target Audience: 一般
• Note (General): doctoral; 医学系研究科; Suprabasin (SBSN) is expressed not only in epidermis but also in epithelial cells of the upper digestive tract where metals such as nickel are absorbed. We have recently shown that SBSN level is decreased in the stratum corneum and serum of atopic dermatitis (AD) patients, especially in intrinsic AD, which is characterized by metal allergy. By using SBSN-null (Sbsn-/-) mice, this study was conducted to investigate the outcome of SBSN deficiency in relation to AD. Sbsn-/- mice exhibited skin barrier dysfunction on embryonic day 16.5, but after birth, their barrier function was not perturbed despite the presence of ultrastructural changes in stratum corneum and keratohyalin granules. Sbsn-/- mice showed a comparable ovalbumin-specific skin immune response to wild type (WT) mice and rather lower contact hypersensitivity (CHS) responses to haptens than did WT mice. The blood nickel level after oral feeding of nickel was significantly higher in Sbsn-/- mice than in WT mice, and CHS to nickel was elevated in Sbsn-/- mice under nickel-loading condition. Our study suggests that the completely SBSN deficient mice retain normal barrier function, but harbor abnormal upper digestive tract epithelium that promotes nickel absorption and high CHS to nickel, sharing the features of intrinsic AD.
• DOI: info:doi/10.1038/s41598-020-71536-3; https://doi.org/info:doi/10.1038/s41598-020-71536-3
• Persistent ID (NDL): info:ndljp/pid/11710996; https://dl.ndl.go.jp/pid/11710996
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2021-08-09T17:15:52+09:00
• Date Created (W3CDTF): 2021-06-08
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10271/00003856; https://hama-med.repo.nii.ac.jp/records/3727
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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