Low-Dose of Intrapulmonary Pirfenidone Improves Human Transforming Growth Factorβ1-Driven Lung Fibrosis

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Low-Dose of Intrapulmonary Pirfenidone Improves Human Transforming Growth Factorβ1-Driven Lung Fibrosis

Persistent ID (NDL): info:ndljp/pid/11711063

Material type: 博士論文

Author: Okano, Tomohito

Publisher: 三重大学

Publication date: 2021-03-25

Material Format: Digital

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Name of awarding university/degree: 三重大学,博士(医学)

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Note (General)：: application/pdfIdiopathic pulmonary fibrosis is a chronic, progressive, and lethal lung disease of unknown etiology. Antifibrotic drugs, including pir...

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Material Type: 博士論文
Title: Low-Dose of Intrapulmonary Pirfenidone Improves Human Transforming Growth Factorβ1-Driven Lung Fibrosis
Author/Editor: Okano, Tomohito
Author Heading: Okano, Tomohito
Publication, Distribution, etc.: 三重大学
Publication Date: 2021-03-25
Publication Date (W3CDTF): 2021-03-25
Degree grantor/type: 三重大学
Date Granted: 2021-03-25
Date Granted (W3CDTF): 2021-03-25
Dissertation Number: 甲医学第2059号
Degree Type: 博士(医学)
Conferring No. (Dissertation): 甲医学第2059号
Text Language Code: eng
Alias of Author: オカノ, トモヒト
岡野, 智仁
Subject Heading: idiopathic pulmonary fibrosis
pirfenidone
intrapulmonary delivery
oral therapy
adverse effects
drug delivery
Target Audience: 一般
Note (General): application/pdf
Idiopathic pulmonary fibrosis is a chronic, progressive, and lethal lung disease of unknown etiology. Antifibrotic drugs, including pirfenidone, are currently used for the treatment of the disease. The oral administration of pirfenidone is an effective therapy, as demonstrated by several clinical trials, although it causes severe adverse events in some patients. We hypothesized that low-dose intrapulmonary delivery of pirfenidone is effective in human transforming growth factorβ1-driven pulmonary fibrosis. To demonstrate our hypothesis, we compared the therapeutic efficacy of varying doses of pirfenidone administered by oral and intranasal routes in a human transforming growth factorβ1 transgenic mouse with established pulmonary fibrosis. We found similar amelioration of lung cell infiltration, inflammatory and fibrotic cytokines, lung fibrosis score, and hydroxyproline content in mice with human transforming growth factorβ1-mediated pulmonary fibrosis treated with low-dose intranasal pirfenidone and high-dose oral pirfenidone. This study showed that pirfenidone is a potent inhibitor of human transforming growth factorβ1-driven lung fibrosis and that intrapulmonary delivery of low-dose pirfenidone produces therapeutic responses equivalent to high-dose of oral pirfenidone.
本文/Department of Pulmonary and Critical Care Medicine, Mie University Faculty and Graduate School of Medicine, Tsu, Japan
13p
DOI: info:doi/10.3389/fphar.2020.593620
https://doi.org/info:doi/10.3389/fphar.2020.593620
Persistent ID (NDL): info:ndljp/pid/11711063
https://dl.ndl.go.jp/pid/11711063
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2021-08-09T17:15:52+09:00
Date Created (W3CDTF): 2021-06-29
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://hdl.handle.net/10076/00019689
https://mie-u.repo.nii.ac.jp/records/14071
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp